Familial cold urticaria (hives)
About Familial cold urticaria (hives)
A rare inherited disorder that causes hives (urticaria) after exposure to cold. Other symptoms such as fever and joint pain may be prominent. These episodes are triggered by exposure to cold and may last hours to a few days. Familial cold urticaria is also known as familial cold auto-inflammatory syndrome. The first episodes usually occur during infancy and last throughout a person's life.Symptoms
Rash (hives), fever, itching, and joint pain after exposure to cold.Tests & Diagnostics
A history and physical exam will be performed. Genetic testing may be recommended.OTC sleep aids and supportive treatments
Prescription medications
Conventional treatment summary
Treatment includes steroids, and antihistamines (such as diphenhydramine/Benadryl) for the itching. When symptoms are significant and not well controlled with antihistamines alone, injectable medications such as anakinra (Kineret) or canakinumab (Ilaris) may be effective.Medical specialties
Internal Medicine · Pediatrics · Family Practice · Allergy and Immunology · Pediatric Allergy and Immunology
This page is educational content, not medical advice. Always consult a qualified clinician for diagnosis and treatment of Familial cold urticaria (hives).