Premature ovarian failure
About Premature ovarian failure
The failure of the ovaries before age 40. The ovaries stop producing the normal amount of hormones causing infertility, osteoporosis, and depression. Premature ovarian failure is different than premature menopause. Women with premature menopause stop having periods and cannot become pregnant while those with premature ovarian failure may still have irregular periods and even become pregnant. The most common causes of premature ovarian failure are: chromosomal problems such as Turner's syndrome, ovarian damage secondary to chemotherapy or radiation, and autoimmune diseases.Symptoms
Inability to become pregnant (infertility), hot flashes, missed periods, vaginal dryness, problems concentrating, depression, decreased sexual desire.Tests & Diagnostics
A history and physical exam will be done. A pregnancy test (serum HCG) will be done to rule out pregnancy. Other tests include a follicle stimulating hormone (FSH) test, a luteinizing hormone (LH) test and a serum estradiol test. An analysis of the chromosomes may also be performed.Prescription medications
Conventional treatment summary
Estrogen is given to prevent osteoporosis and treat the hot flashes and emotional symptoms of the disorder. The estrogen can be given as a pill, patch, cream or through a vaginal ring. Progesterone is commonly prescribed along with the estrogen. Calcium and vitamin D are given as well. Unfortunately these treatments typically do not reverse the infertility. A small subset of patients who have persistent fatigue and low sex drive may be given male hormones (androgens).Medical specialties
Obstetrics and Gynecology
This page is educational content, not medical advice. Always consult a qualified clinician for diagnosis and treatment of Premature ovarian failure.