Quaternary syphilis (late syphilis, neurosyphilis, cardiovascular syphilis)
About Quaternary syphilis (late syphilis, neurosyphilis, cardiovascular syphilis)
An advanced form of syphilis. Syphilis is caused by the bacteria Treponema pallidum. Quaternary syphilis is syphilis in late stages that has involved the heart or brain (neurosyphilis). Neurosyphilis is a progressive and advanced brain infection (encephalitis). Patients may have dementia, personality changes, unsteady gait, visual problems, stroke symptoms and seizures.Symptoms
Memory loss (dementia), personality changes, unsteady gait, incoordination, seizures, weakness, confusion, headaches, visual loss.Tests & Diagnostics
A history and physical exam will be performed. A CT scan and/or MRI is done to rule our other causes of the symptoms. A lumbar puncture is done to evaluate the CSF (cerebrospinal fluid), and detect the bacteria through antibody markers (RPR, VDRL).Common tests: Complete blood count (CBC), Comprehensive metabolic panel (CMP), CT Scan, MRI.
Conventional treatment summary
High dose penicillin through an IV is the treatment of choice.Medical specialties
Neurology
This page is educational content, not medical advice. Always consult a qualified clinician for diagnosis and treatment of Quaternary syphilis (late syphilis, neurosyphilis, cardiovascular syphilis).