Erythema multiforme
About Erythema multiforme
Erythema multiforme is a skin reaction that occurs after being exposed to certain medications (barbiturates, phenytoin/Dilantin, nonsteroidal anti-inflammatory drugs/Motrin, penicillins, phenothiazines, sulfa drugs) or infections (herpes simplex virus/HSV, Epstein-Barr virus/EBV, and histoplasmosis). The rash usually resolves on its own and it is often recurrent and most affected individuals can expect 1-2 additional episodes after the initial outbreak. The rash has a characteristic target appearance with round, red borders and central clearing. Individuals with weakened immune systems are at most risk for development of erythema multiforme.Symptoms
Symptoms include the abrupt onset of a round red rash with raised borders and central clearing. Many individuals will experience fever, cough, sore throat and nausea before the rash appears. A variant of erythema multiforme called erythema multiforme major or Steven Johnson syndrome may cause more serious symptoms with ulcerations of the mouth and genitals occur along with redness of the eyes.Tests & Diagnostics
A history and physical will be performed. The diagnosis can usually be made on exam. Occasionally, a skin biopsy may be required to confirm the diagnosis.Common tests: Skin biopsy.
OTC sleep aids and supportive treatments
Prescription medications
Conventional treatment summary
Treatment involves discontinuation of any new medications started within the last two months. Symptoms are treated with tylenol, antihistamines and occasionally, topical steroids. Oral steroids are used in more severe cases, but are considered controversial.Medical specialties
Internal Medicine · Dermatology · Pediatrics · Family Practice
This page is educational content, not medical advice. Always consult a qualified clinician for diagnosis and treatment of Erythema multiforme.