Myasthenia gravis
About Myasthenia gravis
An autoimmune disorder characterized by progressive fatigue and muscle weakness. Muscle strength may be normal at the beginning of a task such as talking; then it becomes progressively weaker as the activity continues. Antibodies block, alter, or destroy the receptors for acetylcholine at the neuromuscular junction, preventing normal muscle contraction. It is more common in young females. It is sometimes associated with a tumor of the thymus (thymoma).Symptoms
Muscle weakness, muscle weakness that becomes worse as the activity continues and returns after rest, double vision, slurred speech, swallowing problems.Tests & Diagnostics
A history and physical exam will be performed. The following tests are done to confirm the diagnosis: EMG, acetylcholine receptor antibodies, and/or Tensilon (edrophonium) test. A chest CT or MRI scan may be done to look for a thymus tumor (thymoma).Common tests: CT Scan, MRI.
Prescription medications
Conventional treatment summary
No known cure is available and treatment is aimed at reducing the weakness. Medications to increase the amount of acetylcholine at the muscle receptor are prescribed (neostigmine, pyridostigmine). Medications to suppress the immune system may be recommended (prednisone, azathioprine, cyclosporine, mycophenolate mofetil). Symptoms can vary. Severe symptoms may be treated with plasmapheresis or intravenous immunoglobulin. For more information contact: Myasthenia Gravis Foundation: (800)541-5454Medical specialties
Neurology · Pediatric Neurology
This page is educational content, not medical advice. Always consult a qualified clinician for diagnosis and treatment of Myasthenia gravis.