Alemtuzumab Injection

Alemtuzumab injection is used to treat B-chronic lymphocytic leukemia (a slowly developing cancer in which too many of a certain type of white blood cell accumulate in the body). Alemtuzumab is in a class of medications called monoclonal antibodies. It works by activating the immune system to destroy cancer cells.

Alemtuzumab injection comes as a solution (liquid) to be injected intravenously (into a vein) over at least 2 hours by a doctor or nurse in a hospital or medical office. At first, alemtuzumab injection is usually given in gradually increasing doses for 3 to 7 days to allow the body to adjust to the medication. Once the body has adjusted to the needed dose of alemtuzumab injection, the medication is usually given three times weekly on alternate days (usually Monday, Wednesday, and Friday) for up to 12 weeks. The medications you receive before each dose of alemtuzumab injection might make you sleepy. You will probably want to ask a family member or friend to come with you when you receive your medication and to take you home afterward. Although your condition may improve as soon as 4 to 6 weeks after you begin treatment with alemtuzumab injection, your treatment will probably last for 12 weeks. Your doctor will decide whether to continue your treatment and may adjust your dose depending on how well the medication works for you and on the side effects you experience.

<p></p> <p></p> <p></p> <p>Alemtuzumab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

<ul>
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nausea</li>
<li>
vomiting</li>
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stomach pain</li>
<li>
diarrhea</li>
<li>
loss of appetite</li>
<li>
mouth sores</li>
<li>
headache</li>
<li>
anxiety</li>
<li>
difficulty falling asleep or staying asleep</li>
<li>
uncontrollable shaking of a part of the body</li>
<li>
muscle pain</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of the symptoms listed in the IMPORTANT WARNING section, call your doctor immediately.Alemtuzumab injection may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before receiving alemtuzumab injection, tell your doctor and pharmacist if you are allergic to alemtuzumab injection or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. tell your doctor if you have or have ever had any medical conditions. if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving alemtuzumab injection.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include:

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tightening of the throat</li>
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difficulty breathing</li>
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cough</li>
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decreased urination</li>
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unusual bruising or bleeding</li>
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reddish or purple spots on the skin</li>
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pale skin</li>
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weakness</li>
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excessive tiredness</li>
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sore throat, fever, chills, and other signs of infection</li>
<li>
nausea</li>
<li>
vomiting</li>
<li>
hives</li>
<li>
rash</li>
<li>
itching</li>
<li>
swelling of the eyes, face, mouth, throat, lips, or tongue</li>
<li>
fast or irregular heartbeat</li>
<li>
fainting</li>
<li>
chest pain</li></ul>