Bexarotene Topical

Topical bexarotene is used to treat cutaneous T-cell lymphoma (CTCL, a type of skin cancer) that could not be treated with other medications. Bexarotene is in a class of medications called retinoids. It works by stopping the growth of cancer cells.

Topical bexarotene comes as a gel to apply to the skin. It is usually applied once every other day at first and gradually applied more frequently up to two to four times a day. Use topical bexarotene at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use bexarotene exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Your doctor will probably start you on a low dose of topical bexarotene and gradually increase your dose, not more often than once a week. Your doctor may decrease your dose if you experience side effects. Your condition may improve as soon as 4 weeks after you begin to use topical bexarotene, or it may take several months before you notice any improvement. Continue to use topical bexarotene after you notice improvement; your condition may continue to improve. Do not stop using topical bexarotene without talking to your doctor. Bexarotene gel may catch fire. Do not use this medication near a source of heat or near an open flame such as a cigarette. Bexarotene gel is for external use only. Do not swallow the medication and keep the medication away from your eyes, nostrils, mouth, lips, vagina, tip of penis, rectum, and anus. You may bathe, shower, or swim during your treatment with topical bexarotene, but you should use only a mild, non-deodorant soap.You should wait at least 20 minutes after bathing or showering before applying topical bexarotene. After you apply the medication, do not bathe, swim, or shower for at least 3 hours. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. To use the gel, follow these steps:

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Wash your hands.</li>
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If you are using a new tube of bexarotene gel, remove the cap and check that the opening of the tube is covered with a metal safety seal. Do not use the tube if you do not see the safety seal or if the seal has been punctured. If you do see the safety seal, turn the cap upside down and use the sharp point to puncture the seal.</li>
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Use a clean finger to apply a generous layer of gel to the area to be treated only. Be careful not to get any gel on the healthy skin around the affected area. Do not rub the gel into the skin. You should be able to see some gel on the affected area after you are finished applying it.</li>
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Do not cover the treated area with a tight bandage or dressing unless you were told to do so by your doctor.</li>
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Wipe the finger that you used to apply the gel with a tissue and throw the tissue away. Wash your hands with soap and water.</li>
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Allow the gel to dry for 5-10 minutes before covering with loose clothing. Do not wear tight clothing over the affected area.</li></ul>

<p></p> <p></p> <p></p> <p>Topical bexarotene may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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itching</li>
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redness, burning, irritation, or scaling of the skin</li>
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rash</li>
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pain</li>
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sweating</li>
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weakness</li>
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headache</li>
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swelling of the arms, hands, feet, ankles, or lower legs</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

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sore throat, fever, chills, or other signs of infection</li>
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swollen glands</li></ul>Bexarotene may cause other side effects. Call your doctor if you have any unusual problems while using this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before using topical bexarotene, tell your doctor and pharmacist if you are allergic to bexarotene; any other retinoid such as acitretin (Soriatane), etretinate (Tegison), isotretinoin (Accutane), or tretinoin (Vesanoid); or any other medications. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungals such as ketoconazole (Nizoral) and itraconazole (Sporanox);erythromycin (E.E.S., E-Mycin, Erythrocin); gemfibrozil (Lopid); other medications or products that are applied to the skin; and vitamin A (in multivitamins). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with topical bexarotene, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. tell your doctor if you have or have ever had kidney or liver disease. plan to avoid unnecessary or prolonged exposure to sunlight and sunlamps and to wear protective clothing, sunglasses, and sunscreen. Topical bexarotene may make your skin sensitive to sunlight. do not use insect repellants or other products containing DEET during your treatment with topical bexarotene. do not scratch the affected areas during your treatment with topical bexarotene.