Bismuth Subsalicylate, Metronidazole, and Tetracycline Combination

Bismuth subsalicylate, metronidazole, and tetracycline combination is used to treat duodenal ulcers. It fights infection by Helicobacter pylori bacteria, which often occurs with ulcers. Treating this infection keeps ulcers from coming back. It usually is used in combination with other ulcer medicines. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Bismuth subsalicylate, metronidazole, and tetracycline combination comes as four pills: two pink, round, chewable tablets (bismuth subsalicylate), one white tablet (metronidazole), and one pale orange and white capsule (tetracycline). It usually is taken four times a day at meals and bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take this medication exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Chew and swallow the bismuth subsalicylate tablets. Swallow the metronidazole tablet and tetracycline capsule whole with a full glass of water (8 ounces [240 milliliters]). Avoid taking this medication with dairy products or milk. Take the bedtime dose with plenty of fluid to prevent irritation of your throat and stomach. Continue to take this medication even if you feel well. Most people will take it for 14 days. Do not stop taking it without talking to your doctor.

<p></p> <p></p> <p></p> <p>Bismuth subsalicylate, metronidazole, and tetracycline combination may cause side effects. Darkening of the tongue and stool is temporary and harmless. Tell your doctor if any of these symptoms are severe or do not go away:

<ul>
<li>
headache</li>
<li>
blurred vision</li>
<li>
dizziness</li>
<li>
nausea</li>
<li>
diarrhea</li>
<li>
constipation</li>
<li>
loss of appetite</li>
<li>
stomach discomfort</li></ul></p> <p></p> <p>If you have any of the following symptoms, stop taking this medication and call your doctor immediately:

<ul>
<li>
numbness in your hands or feet</li>
<li>
seizures</li>
<li>
confusion or agitation</li>
<li>
ringing in the ears</li>
<li>
bloody, black, or tarry stools</li></ul>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before taking bismuth subsalicylate, metronidazole, and tetracycline combination, tell your doctor and pharmacist if you are allergic to bismuth subsalicylate, metronidazole (Flagyl), aspirin or salicylates, tetracycline, or any other drugs. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially oral contraceptives and medications that contain aspirin, antibiotics, or anticoagulants ('blood thinners') such as warfarin (Coumadin), and vitamins. tell your doctor if you have or have ever had kidney, blood, liver, or Crohn's disease. remember not to drink alcoholic beverages while taking this medication and for at least 1 day after treatment is finished. Metronidazole causes severe vomiting and illness when taken before or after drinking alcohol. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. This medication may make your skin sensitive to sunlight.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.