Cabazitaxel Injection

Cabazitaxel injection is used along with prednisone to treat prostate cancer (cancer of a male reproductive organ) that has already been treated with other medications. Cabazitaxel injection is in a class of medications called microtubule inhibitors. It works by slowing or stopping the growth of cancer cells.

Cabazitaxel injection comes as a liquid to be given intravenously (into a vein) over 1 hour by a doctor or nurse in a medical facility. It is usually given once every 3 weeks. You will need to take prednisone every day during your treatment with cabazitaxel injection. It is important that you take prednisone exactly as prescribed by your doctor. Tell your doctor if you have missed doses or have not taken prednisone as prescribed. Your doctor may need to stop or delay your treatment or decrease your dose if you experience certain severe side effects. Be sure to tell your doctor how you are feeling during your treatment. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

<p></p> <p></p> <p></p> <p>Cabazitaxel injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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nausea</li>
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heartburn</li>
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constipation</li>
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stomach pain</li>
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change in ability to taste food</li>
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loss of appetite</li>
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weight loss</li>
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swelling of the inside of the mouth</li>
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headache</li>
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joint or back pain</li>
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numbness, burning, or tingling in the hands, arms, feet, or legs</li>
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hair loss</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

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diarrhea</li>
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vomiting</li>
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swelling of the face, arms, hands, feet, ankles, or lower legs</li>
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decreased urination</li>
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blood in the urine</li>
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dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration</li>
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irregular heartbeat</li>
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shortness of breath</li>
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pale skin</li>
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tiredness or weakness</li>
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unusual bruising or bleeding</li></ul>Cabazitaxel injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before receiving cabazitaxel injection, tell your doctor and pharmacist if you are allergic to cabazitaxel injection, any other medications, polysorbate 80, or any of the other ingredients in cabazitaxel injection. Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: antifungals such as ketoconazole (Nizoral), itraconazole (Sporanox), and voriconazole (Vfend); clarithromycin (Biaxin); certain medications for human immunodeficiency virus (HIV) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), and phenobarbital; nefazodone; rifabutin (Mycobutin), rifapentin (Priftin); rifampin (Rimactin, in Rifamate, in Rifater); and telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with cabazitaxel injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. tell your doctor what herbal products you are taking, especially St. John's wort. tell your doctor if you have or have ever had liver or kidney disease. if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving cabazitaxel injection.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include the following:

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sore throat, cough, fever, chills, muscle aches, burning on urination, or other signs of infection</li>
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unusual bruising or bleeding</li>
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pale skin</li>
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shortness of breath</li>
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excessive tiredness or weakness</li>
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nausea</li>
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vomiting</li>
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diarrhea</li></ul>