Clomiphene

Why this is used

Clomiphene is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant (infertility). Clomiphene is in a class of medications called ovulatory stimulants. It works similarly to estrogen, a female hormone that causes eggs to develop in the ovaries and be released.

How to take it

Clomiphene comes as a tablet to take by mouth. It is usually taken once a day for 5 days, beginning on or about day 5 of the cycle. To help you remember to take clomiphene, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clomiphene exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Side effects

<p></p> <p></p> <p></p> <p>Clomiphene may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

<ul>
<li>
flushing (feeling of warmth)</li>
<li>
upset stomach</li>
<li>
vomiting</li>
<li>
breast discomfort</li>
<li>
headache</li>
<li>
abnormal vaginal bleeding</li></ul></p> <p></p> <p>Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

<ul>
<li>
blurred vision</li>
<li>
visual spots or flashes</li>
<li>
double vision</li>
<li>
stomach or lower stomach pain</li>
<li>
stomach swelling</li>
<li>
weight gain</li>
<li>
shortness of breath</li></ul>Long-term use of clomiphene may increase the risk of ovarian cancer. Clomiphene should not be used for more than about six cycles. Talk to your doctor about the risks of taking this medication.Clomiphene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Precautions

Before taking clomiphene, tell your doctor and pharmacist if you are allergic to clomiphene or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. tell your doctor if you have or have ever had liver disease, ovarian cysts (except those from polycystic ovary syndrome), uterine fibroids, abnormal vaginal bleeding, a pituitary tumor, or thyroid or adrenal disease. you should know that clomiphene may cause blurred vision. Do not drive a car or operate machinery, especially in poor lighting, until you know how this medication affects you. you should know that clomiphene increases the chance of multiple pregnancy (twins or more). Talk to your doctor about the risks of multiple pregnancy.

Overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include:

<ul>
<li>
upset stomach</li>
<li>
vomiting</li>
<li>
hot flashes</li>
<li>
blurred vision</li>
<li>
visual spots or flashes</li>
<li>
blind spots</li>
<li>
stomach swelling</li>
<li>
stomach or lower stomach pain</li></ul>
Educational reference only — talk to a pharmacist or prescriber about Clomiphene.