Danazol
Why this is used
Danazol is used to treat endometriosis, a disease that causes infertility, pain before and during menstrual periods, pain during and after sexual activity, and heavy or irregular bleeding. Danazol is also used in fibrocystic breast disease to reduce breast pain, tenderness, and nodules (lumps). Danazol is also used to prevent attacks of angioedema in both males and females. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How to take it
Danazol comes as a capsule to take by mouth. It usually is taken twice a day. Women should take the first dose during a menstrual period and take it continuously thereafter. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take danazol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Do not stop taking danazol without talking to your doctor. If you have fibrocystic breast disease, breast pain and tenderness usually improve during the first month that you take danazol and go away in 2-3 months; nodules should improve in 4-6 months.
Side effects
<p></p> <p></p> <p></p> <p>Danazol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
<ul>
<li>
acne</li>
<li>
decrease in breast size</li>
<li>
deepening of the voice, hoarseness, or sore throat</li>
<li>
weight gain</li>
<li>
swelling (water retention and bloating)</li>
<li>
oily skin or hair</li>
<li>
hair growth in unusual amounts and places</li>
<li>
flushing</li>
<li>
sweating</li>
<li>
vaginal dryness, burning, itching, or bleeding</li>
<li>
nervousness</li>
<li>
depression</li>
<li>
irritability</li>
<li>
absence of menstrual cycle, spotting, or change in menstrual cycle</li></ul></p> <p></p> <p>If you experience any of the following symptoms, call your doctor immediately:
<ul>
<li>
skin rash</li>
<li>
yellowing of the skin or eyes</li>
<li>
persistent headache</li>
<li>
persistent upset stomach</li>
<li>
vomiting</li>
<li>
visual disturbances</li>
<li>
persistent abdominal pain</li>
<li>
for males, frequent, prolonged, or painful penile erections</li></ul>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>
<ul>
<li>
acne</li>
<li>
decrease in breast size</li>
<li>
deepening of the voice, hoarseness, or sore throat</li>
<li>
weight gain</li>
<li>
swelling (water retention and bloating)</li>
<li>
oily skin or hair</li>
<li>
hair growth in unusual amounts and places</li>
<li>
flushing</li>
<li>
sweating</li>
<li>
vaginal dryness, burning, itching, or bleeding</li>
<li>
nervousness</li>
<li>
depression</li>
<li>
irritability</li>
<li>
absence of menstrual cycle, spotting, or change in menstrual cycle</li></ul></p> <p></p> <p>If you experience any of the following symptoms, call your doctor immediately:
<ul>
<li>
skin rash</li>
<li>
yellowing of the skin or eyes</li>
<li>
persistent headache</li>
<li>
persistent upset stomach</li>
<li>
vomiting</li>
<li>
visual disturbances</li>
<li>
persistent abdominal pain</li>
<li>
for males, frequent, prolonged, or painful penile erections</li></ul>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>
Precautions
Before taking danzaol, tell your doctor and pharmacist if you are allergic to danazol or any other drugs. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants ('blood thinners') such as warfarin (Coumadin); diabetes medications such as insulin; medications to prevent seizures, especially carbamazepine (Tegretol); and vitamins. tell your doctor if you have or have ever had migraine headaches; heart, liver, or kidney disease; seizures (epilepsy); or a history of stroke, blood clots, or breast cancer.
Overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Educational reference only — talk to a pharmacist or prescriber about Danazol.