Etravirine

Etravirine is used with other medications to treat human immunodeficiency virus (HIV) infection in people with or without acquired immunodeficiency syndrome (AIDS) whose HIV infection has not been controlled with other medications. Etravirine is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by slowing the spread of HIV in the body. Etravirine does not cure HIV infection and may not prevent you from developing HIV-related illnesses. Etravirine does not prevent you from spreading HIV to other people.

Etravirine comes as a tablet to take by mouth. It is usually taken after a meal two times a day. Take etravirine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take etravirine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow the tablets whole with liquid, such as water; do not split, chew, or crush them. If you have trouble swallowing the tablets, they may be dissolved in water. To prepare, add the tablets to a glass of water, allow to stand for a few minutes, and then stir until a milky mixture occurs. Drink the etravirine-water mixture right away. Rinse the glass with water and swallow the entire contents. Repeat process of rinsing and swallowing the rinse mixture several times to make sure that the entire dose is taken. Etravirine helps to control HIV infection, but does not cure it. Continue to take etravirine even if you feel well. Do not stop taking etravirine without talking to your doctor. If you stop taking etravirine or miss doses, your condition may become more difficult to treat. When your supply of etravirine starts to run low, get more from your doctor or pharmacist. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

<p></p> <p></p> <p></p> <p>Etravirine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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nausea</li>
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vomiting</li>
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abdominal pain</li>
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diarrhea</li>
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headache</li>
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increase in blood pressure</li>
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pain, burning, numbness, or tingling in the hands or feet</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of these symptoms, stop taking etravirine and call your doctor immediately:

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rash</li>
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redness, bumps, or blisters on the skin or in the mouth</li>
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redness or swelling of the eyes</li>
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swelling of the face</li>
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sore throat, cough, fever, chills, or other signs of infection</li>
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general ill feeling</li>
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tiredness</li>
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muscle or joint aches</li>
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yellowing of the skin or eyes</li>
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dark-colored urine</li>
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pale-colored stools</li>
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pain in the upper right part of the stomach</li>
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loss of appetite</li></ul>Etravirine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before taking etravirine, tell your doctor and pharmacist if you are allergic to etravirine, or any other medications. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antiarrhythmics (medications to treat abnormal heart beats) including amiodarone (Cordarone), bepridil (Vascor), disopyramide (Norpace), flecainide (Tambocor), lidocaine (Xylocaine), mexiletine (Mexitil), propafenone (Rythmol), and quinidine (Quinidex); certain medications to treat seizures such as carbamazepine (Tegretol, Carbatrol), phenobarbital (Luminal), and phenytoin (Dilantin, Phenytek); clarithromycin (Biaxin, in Prevpac); cholesterol-lowering medications (statins) including atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Advicor, Altoprev, Mevacor), rosuvastatin (Crestor), and simvastatin (Vytorin, Zocor); clopidogrel (Plavix); diazepam (Valium); dexamethasone (Decadron, Dexone, others); certain medications that suppress the immune system such as cyclosporine (Sandimmune, Neoral), sirolimus (Rapamune), and tacrolimus (Prograf); medications to treat erectile dysfunction including sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra); medications to treat fungal infections including fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); methadone (Dolophine); other medications to treat HIV including amprenavir (Agenerase) atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), and nevirapine (Viramune) ritonavir (Norvir, in Kaletra), and tipranavir (Aptivus); rifabutin (Mycobutin); rifampin (Rifadin, Rifater, Rifamate); rifapentine (Priftin). Many other medications may also interact with etravirine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Do not start taking any new medications while you are taking etravirine without first talking with your doctor or pharmacist. tell your doctor what herbal products you are taking, especially St. John's wort. tell your doctor if you have or have ever had liver disease, including hepatitis. you should know that your body fat may increase or move to different areas of your body such as your breasts, neck, chest, stomach, and upper back. Loss of fat from your legs, arms, and face may also happen.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.