Fluvoxamine
Why this is used
Fluvoxamine is used to treat obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over) and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). Fluvoxamine is in a class of medications called selective serotonin reuptake inhibitors (SSRIs).
How to take it
Fluvoxamine comes as a tablet and an extended-release capsule to take by mouth. The tablet usually is taken either once daily at bedtime or twice daily, once in the morning and once at bedtime. The extended-release capsule usually is taken, with or without food , once daily at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take fluvoxamine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow the extended-release capsules whole; do not be crush or chew them. Your doctor may start you on a low dose of fluvoxamine and gradually increase your dose, not more often than once every week, depending on how well the medication works for you and the side effects you experience. It may take several weeks or longer for you to feel the full benefit of fluvoxamine. Continue to take fluvoxamine even if you feel well. Do not stop taking fluvoxamine without talking to your doctor. If you suddenly stop taking fluvoxamine, you may experience withdrawal symptoms such as irritability; agitation; dizziness; extreme worry; uneasiness; confusion; headache; tiredness; mood changes; difficulty falling asleep or staying asleep; or pain, burning, numbness, tingling or 'electric shock' sensations in the hands or feet. Your doctor probably will decrease your dose gradually.
Side effects
<p></p> <p></p> <p></p> <p>Fluvoxamine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
<ul>
<li>
drowsiness</li>
<li>
difficulty concentrating, memory problems, or confusion</li>
<li>
dry mouth</li>
<li>
headache</li>
<li>
nausea</li>
<li>
vomiting</li>
<li>
diarrhea</li>
<li>
stomach pain</li>
<li>
constipation</li>
<li>
indigestion</li>
<li>
gas</li>
<li>
change in taste</li>
<li>
decreased appetite</li>
<li>
weight loss</li>
<li>
nervousness</li>
<li>
weakness</li>
<li>
unsteadiness</li>
<li>
changes in sex drive or ability</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of the following symptoms, or those listed in the IMPORTANT WARNING section, call your doctor immediately:
<ul>
<li>
chest pain</li>
<li>
problems with coordination</li>
<li>
dizziness</li>
<li>
hallucination (seeing things or hearing voices that do not exist)</li>
<li>
fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness</li>
<li>
pain, burning, numbness, or tingling in the hands or feet</li>
<li>
shaking of a part of the body that you cannot control</li>
<li>
rash</li>
<li>
hives</li>
<li>
slowed or difficult breathing</li>
<li>
seizures</li>
<li>
loss of consciousness</li>
<li>
unusual bleeding or bruising</li>
<li>
bloody nose</li>
<li>
vomiting blood or a material that looks like coffee grounds</li>
<li>
red blood in stool or black and tarry stools</li></ul>Fluvoxamine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>
<ul>
<li>
drowsiness</li>
<li>
difficulty concentrating, memory problems, or confusion</li>
<li>
dry mouth</li>
<li>
headache</li>
<li>
nausea</li>
<li>
vomiting</li>
<li>
diarrhea</li>
<li>
stomach pain</li>
<li>
constipation</li>
<li>
indigestion</li>
<li>
gas</li>
<li>
change in taste</li>
<li>
decreased appetite</li>
<li>
weight loss</li>
<li>
nervousness</li>
<li>
weakness</li>
<li>
unsteadiness</li>
<li>
changes in sex drive or ability</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of the following symptoms, or those listed in the IMPORTANT WARNING section, call your doctor immediately:
<ul>
<li>
chest pain</li>
<li>
problems with coordination</li>
<li>
dizziness</li>
<li>
hallucination (seeing things or hearing voices that do not exist)</li>
<li>
fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness</li>
<li>
pain, burning, numbness, or tingling in the hands or feet</li>
<li>
shaking of a part of the body that you cannot control</li>
<li>
rash</li>
<li>
hives</li>
<li>
slowed or difficult breathing</li>
<li>
seizures</li>
<li>
loss of consciousness</li>
<li>
unusual bleeding or bruising</li>
<li>
bloody nose</li>
<li>
vomiting blood or a material that looks like coffee grounds</li>
<li>
red blood in stool or black and tarry stools</li></ul>Fluvoxamine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>
Precautions
Before taking fluvoxamine, tell your doctor and pharmacist if you are allergic to fluvoxamine or any other medications. tell your doctor if you are taking alosetron (Lotronex), astemizole (Hismanal) (not available in the U.S.), cisapride (Propulsid) (not available in the U.S.), pimozide (Orap), ramelteon (Rozerem), terfenadine (Seldane) (not available in the US), tizanidine (Zanaflex), or thioridazine. Your doctor will probably tell you not to take fluvoxamine. tell your doctor if you are taking the following medications or if you have stopped taking them within the past 2 weeks: monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Your doctor will probably tell you not to take fluvoxamine. tell your doctor and pharmacist what prescription and nonprescription medications, and vitamins you are taking or plan to take. Be sure to mention any of the following: alprazolam (Xanax); anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin or aspirin-containing products and other nonsteroidal anti-inflammatory drugs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); beta-blockers such as metoprolol (Lopressor, Toprol) and propranolol (Inderal, in Inderide); buspirone (BuSpar); carbamazepine (Tegretol); clopidogrel (Plavix), clozapine (Clozaril); cyclosporine (Neoral, Sandimmune); dextromethorphan (in cough medications); diazepam (Valium); diltiazem (Cardizem); diuretics ('water pills'); haloperidol (Haldol); ketoconazole (Nizoral); lithium;medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); methadone (Dolophine, Methadose); mexiletine (Mexitil); metoclopramide; midazolam (Versed); omeprazole (Prilosec, Zegerid); other medications for anxiety, depression, or mental illness; phenytoin (Dilantin);sibutramine (Meridia); tacrine (Cognex); theophylline (Theo-Dur); tramadol (Ultram, in Ultracet); triazolam (Halcion); and quinidine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor what herbal products and nutritional supplements you are taking, especially products that contain St. John's wort and tryptophan. tell your doctor if you drink or have ever drunk large amounts of alcohol or have used street drugs or have overused prescription medications. Also tell your doctor if you have or have ever had seizures, or heart, kidney, adrenal, or liver disease. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking fluvoxamine. you should know that this medication may make you drowsy or affect your judgment, thinking, or motor skills. Do not drive a car or operate machinery until you know how this medication affects you. remember that alcohol can add to the drowsiness caused by this medication. You should not drink alcohol while taking fluvoxamine. tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.
Overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include:
<ul>
<li>
enlarged pupils (black circle in center of eye)</li>
<li>
unsteadiness</li>
<li>
dizziness</li>
<li>
drowsiness</li>
<li>
nausea</li>
<li>
vomiting</li>
<li>
diarrhea</li>
<li>
difficulty breathing</li>
<li>
changes in heartbeat</li>
<li>
shaking of a part of the body that you cannot control</li>
<li>
seizure</li>
<li>
changes in alertness</li>
<li>
loss of consciousness</li></ul>
<ul>
<li>
enlarged pupils (black circle in center of eye)</li>
<li>
unsteadiness</li>
<li>
dizziness</li>
<li>
drowsiness</li>
<li>
nausea</li>
<li>
vomiting</li>
<li>
diarrhea</li>
<li>
difficulty breathing</li>
<li>
changes in heartbeat</li>
<li>
shaking of a part of the body that you cannot control</li>
<li>
seizure</li>
<li>
changes in alertness</li>
<li>
loss of consciousness</li></ul>
Educational reference only — talk to a pharmacist or prescriber about Fluvoxamine.