Ganciclovir

Ganciclovir capsules are used to treat cytomegalovirus (CMV) retinitis (eye infection that can cause blindness) in people whose immune system is not working normally. Ganciclovir capsules are used to treat CMV retinitis after the condition has been controlled by intravenous (injected into a vein) ganciclovir. Ganciclovir is also used to prevent cytomegalovirus (CMV) disease in people who have acquired immunodeficiency syndrome (AIDS) or who have received an organ transplant and are at risk of CMV disease.Ganciclovir is in a class of medications called antivirals. It works by preventing the spread of CMV disease or slowing the growth of CMV.

Ganciclovir comes as a capsule to take by mouth. It is usually taken with food three to six times a day.To help you remember to take ganciclovir, take it at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ganciclovir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow the capsules whole; do not open, split, chew, or crush them. Be careful when handling ganciclovir capsules. Do not allow your skin, eyes, mouth, or nose to come into contact with broken or crushed ganciclovir capsules. If such contact occurs, wash your skin well with soap and water or rinse your eyes well with plain water. You generally will receive intravenous (into a vein) ganciclovir for several weeks before you begin to take ganciclovir capsules. If your condition gets worse during your treatment, you may be given a second course of intravenous ganciclovir. Your doctor may decrease your dose of ganciclovir capsules if you experience side effects. Ganciclovir controls CMV but does not cure it.It may take some time before you feel the full benefit of ganciclovir. Continue to take ganciclovir even if you feel well. Do not stop taking ganciclovir without talking to your doctor. Stopping to take ganciclovir too soon may cause the amount of CMV in your blood to increase or the virus to become resistant to this medication.

<p></p> <p></p> <p></p> <p>Ganciclovir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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nausea</li>
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vomiting</li>
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diarrhea</li>
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constipation</li>
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stomach pain</li>
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belching</li>
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loss of appetite</li>
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changes in ability to taste food</li>
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dry mouth</li>
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mouth sores</li>
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unusual dreams</li>
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nervousness</li>
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depression</li>
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sweating</li>
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flushing</li>
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joint or muscle pain or cramps</li></ul></p> <p></p> <p>Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, or those listed in the IMPORTANT WARNING section, call your doctor immediately:

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seeing specks, flashes of light, or a dark curtain over everything</li>
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decreased urination</li>
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hives</li>
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rash</li>
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itching</li>
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swelling of the hands, arms, feet, ankles, or lower legs</li>
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numbness, pain, burning, or tingling in the hands or feet</li>
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shaking hands that you cannot control</li>
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difficulty breathing or swallowing</li>
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chest pain</li>
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mood changes</li>
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seizures</li></ul>Ganciclovir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before taking ganciclovir, tell your doctor and pharmacist if you are allergic to ganciclovir, acyclovir (Zovirax), valganciclovir (Valcyte), or any other medications. do not take ganciclovir if you are taking valganciclovir (Valcyte). tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), neomycin (New-Rx, New-Fradin), netilmicin (Netromycin), streptomycin, tobramycin (Nebcin, Tobi), and others; amphotericin B (Fungizone); captopril (Capoten, in Capozide); diuretics ('water pills'); foscarnet (Foscavir); gold compounds such as auranofin (Ridaura) or aurothioglucose (Solganal); imipenem-cilastatin (Primaxin); immune globulin (gamma globulin, BayGam, Carimmune, Gammagard, others); methicillin (Staphcillin); muromonab-CD3 (OKT3); mycophenolate mofetil (CellCept); nitrates such as isosorbide dinitrate (Isordil, Sorbitrate) or nitroglycerin products; penicillamine (Cuprimine, Depen); primaquine; probenecid; rifampin (Rifadin, Rimactane); or other nucleoside analogues such as acyclovir (Zovirax), famciclovir (Famvir), and ribavirin (Copegus, Rebetol, Virazole, in Rebetron). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or any of the following conditions: mental illness; seizures; eye problems other than CMV retinitis; kidney, or liver disease. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking ganciclovir. you should know that ganciclovir may make you drowsy, dizzy, unsteady, confused or less alert, or may cause seizures. Do not drive a car or operate machinery until you know how this medication affects you.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include:

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nausea</li>
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vomiting</li>
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diarrhea</li>
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loss of appetite</li>
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unusual bleeding or bruising</li>
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excessive tiredness</li>
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weakness</li>
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pale skin</li>
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headache</li>
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dizziness</li>
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confusion</li>
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fast heartbeat</li>
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difficulty sleeping</li>
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shortness of breath</li>
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sore throat, fever, chills, cough, or other signs of infection</li>
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decreased urination</li>
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swelling of the hands, arms, feet, ankles, or lower legs</li>
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seizures</li>
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yellowing of the skin or eyes</li>
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flu-like symptoms</li>
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pain in the upper right part of the stomach</li></ul>