Meclofenamate

Why this is used

Meclofenamate is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve other types of mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). It also may be used to decrease bleeding in women who have abnormally heavy menstrual blood loss. Meclofenamate is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

How to take it

Meclofenamate comes as a capsule to take by mouth. It is usually taken three or four times a day for arthritis, three times a day for heavy menstrual blood loss, or every 4 to 6 hours as needed for pain. Meclofenamate may be taken with food or milk to prevent nausea. If you take meclofenamate regularly, take it at the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take meclofenamate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. If you are taking meclofenamate to reduce heavy menstrual bleeding, your bleeding should decrease during your treatment. Call your doctor if your bleeding does not decrease or if you experience spotting or bleeding between menstrual periods. If you are taking meclofenamate to relieve the symptoms of arthritis, your symptoms may begin to improve within a few days. It may take 2 to 3 weeks or longer for you to feel the full benefit of meclofenamate.

Side effects

<p></p> <p></p> <p></p> <p>Meclofenamate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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diarrhea</li>
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constipation</li>
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gas</li>
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sores in the mouth</li>
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headache</li>
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ringing in the ears</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more meclofenamate until you speak to your doctor.

<ul>
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blurred vision</li>
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unexplained weight gain</li>
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fever</li>
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blisters</li>
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rash</li>
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itching</li>
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hives</li>
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swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs</li>
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hoarseness</li>
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difficulty breathing or swallowing</li>
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yellowing of the skin or eyes</li>
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excessive tiredness</li>
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unusual bleeding or bruising</li>
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lack of energy</li>
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nausea</li>
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loss of appetite</li>
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pain in the upper right part of the stomach</li>
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flu-like symptoms</li>
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pale skin</li>
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fast heartbeat</li>
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cloudy, discolored, or bloody urine</li>
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back pain</li>
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difficult or painful urination</li></ul>Meclofenamate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Precautions

Before taking meclofenamate, tell your doctor and pharmacist if you are allergic to meclofenamate, aspirin, or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in meclofenamate capsules. Ask your pharmacist for a list of the inactive ingredients. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); diuretics ('water pills'); lithium (Eskalith, Lithobid); and methotrexate (Rheumatrex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); swelling of the hands, feet, ankles, or lower legs; or liver or kidney disease. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking meclofenamate.

Overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdoses may include:

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behavior that does not make sense</li>
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agitation</li>
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seizures</li>
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decreased urination</li></ul>
Educational reference only — talk to a pharmacist or prescriber about Meclofenamate.