Midazolam Injection

Midazolam injection is used before medical procedures and surgery to cause drowsiness, relieve anxiety, and prevent any memory of the event. It is also sometimes given as part of the anesthesia during surgery to produce a loss of consciousness. Midazolam injection is also used to cause a state of decreased consciousness in seriously ill people in intensive care units (ICU) who are breathing with the help of a machine. Midazolam injection is in a class of medications called benzodiazepines. It works by slowing activity in the brain to allow relaxation and decreased consciousness.

Midazolam injection comes as a solution (liquid) to be injected into a muscle or vein by a doctor or nurse in a hospital or clinic. If you receive midazolam injection in the ICU over a long period of time, your body may become dependent on it. Your doctor will probably decrease your dose gradually to prevent withdrawal symptoms such as seizures, uncontrollable shaking of a part of the body, hallucinations (seeing things or hearing voices that do not exist), stomach and muscle cramps, nausea, vomiting, sweating, fast heartbeat, difficulty falling asleep or staying asleep, and depression.

<p></p> <p></p> <p></p> <p>Midazolam injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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headache</li>
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drowsiness</li>
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nausea</li>
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vomiting</li>
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hiccups</li>
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coughing</li>
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pain, redness, or hardening of the skin at the injection site</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

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agitation</li>
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restlessness</li>
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uncontrollable shaking of a part of the body</li>
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stiffening and jerking of the arms and legs</li>
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aggression</li>
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seizures</li>
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uncontrollable rapid eye movements</li>
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hives</li>
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rash</li>
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itching</li>
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difficulty breathing or swallowing</li></ul>Midazolam injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before receiving midazolam injection, tell your doctor and pharmacist if you are allergic to midazolam or any other medications. tell your doctor if you are taking certain medications for human immunodeficiency virus (HIV) including amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), fosamprenavir (Lexiva), indinavir (Crixivan),lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus). Your doctor may decide not to give you midazolam injection if you are taking one or more of these medications. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: aminophylline (Truphylline); certain antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); certain calcium channel blockers such as diltiazem (Cartia, Cardizem, Tiazac, others) and verapamil (Calan, Isoptin, Verelan, others); cimetidine (Tagamet); dalfopristin-quinupristin (Synercid); and erythromycin (E-mycin, E.E.S.). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with midazolam, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. tell your doctor if you have glaucoma (increased pressure in the eyes that may cause gradual loss of vision). Your doctor may decide not to give you midazolam injection. tell your doctor if you have recently stopped drinking large amounts of alcohol or if you have or have ever had kidney or liver disease. talk to your doctor about the risks and benefits of receiving midazolam injection if you are 65 years of age or older. Older adults should usually receive lower doses of midazolam injection because higher doses are more likely to cause serious side effects. you should know that midazolam may make you very drowsy and may affect your memory, thinking, and movements. Do not drive a car or do other activities that require you to be fully alert for at least 24 hours after receiving midazolam and until the effects of the medication have worn off. If your child is receiving midazolam injection, watch him or her carefully to be sure that he or she does not fall while walking during this time. you should know that alcohol can make the side effects from midazolam injection worse.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include:

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drowsiness</li>
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confusion</li>
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problems with balance and movement</li>
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slowed reflexes</li>
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slowed breathing and heartbeat</li>
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coma (loss of consciousness for a period of time)</li></ul>