Pantoprazole
Why this is used
Pantoprazole is used to treat gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube between the throat and stomach). Pantoprazole is used to treat the symptoms of GERD, allow the esophagus to heal, and prevent further damage to the esophagus. It is also used to treat conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome. Pantoprazole is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach.
How to take it
Pantoprazole comes as a delayed-release (long-acting) tablet to take by mouth and packets of delayed-release (long-acting) granules to be mixed with applesauce or apple juice and taken by mouth or given through a feeding tube. The tablet is usually taken with or without food one or two times a day. The oral suspension is usually taken 30 minutes before a meal one or two times a day. Take pantoprazole at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pantoprazole exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor. Swallow the tablets whole; do not split, chew, or crush them. If your doctor has prescribed the 40 mg tablet and it is too big for you to swallow, ask your doctor to prescribe two of the 20-mg tablets instead. To take the powder for oral suspension, open the packet and sprinkle the granules onto one teaspoonful of applesauce or into a cup containing one teaspoonful of apple juice. Use all of the granules in the packet; do not divide the granules into smaller doses. If you sprinkle the granules into apple juice, stir the mixture for 5 seconds. Swallow the mixture of applesauce or apple juice and medication right away without chewing or crushing the granules. If you sprinkled the granules on applesauce, take several sips of water to wash the granules down to your stomach. If you sprinkled the granules into apple juice, rinse the cup once or twice with apple juice and drink the apple juice right away to be sure you swallow any leftover granules. Pantoprazole powder mixed with apple juice may be given through a feeding tube. If you have a feeding tube, ask your doctor how you should take pantoprazole. Continue to take pantoprazole even if you feel well. Do not stop taking pantoprazole without talking to your doctor. If your condition does not improve or gets worse, call your doctor.
Side effects
<p></p> <p></p> <p></p> <p>Pantoprazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
<ul>
<li>
headache</li>
<li>
dizziness</li>
<li>
diarrhea</li>
<li>
stomach pain</li>
<li>
nausea</li>
<li>
vomiting</li>
<li>
gas</li>
<li>
joint pain</li></ul>Some side effects may be serious. If you experience any of the following symptoms, call your doctor immediately:
<ul>
<li>
blistering or peeling skin</li>
<li>
rash</li>
<li>
hives</li>
<li>
itching</li>
<li>
swelling of the eyes, face, lips, mouth, throat, or tongue</li>
<li>
difficulty breathing or swallowing</li>
<li>
hoarseness</li>
<li>
irregular, fast, or pounding heartbeat</li>
<li>
excessive tiredness</li>
<li>
dizziness</li>
<li>
lightheadedness</li>
<li>
muscle spasms</li>
<li>
uncontrollable shaking of a part of the body</li>
<li>
seizures</li></ul>Pantoprazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.People who take proton pump inhibitors such as pantoprazole may be more likely to fracture their wrists, hips, or spine than people who do not take one of these medications. The risk is highest in people who take high doses of one of these medications or take them for one year or longer. The risk may also be higher in people who are 50 years of age or older.People who take pantoprazole for a long time may develop weakening of the stomach lining and a low level of vitamin B12 in the blood. Talk to your doctor about the risks of taking pantoprazole.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p> <p></p> <p></p>
<ul>
<li>
headache</li>
<li>
dizziness</li>
<li>
diarrhea</li>
<li>
stomach pain</li>
<li>
nausea</li>
<li>
vomiting</li>
<li>
gas</li>
<li>
joint pain</li></ul>Some side effects may be serious. If you experience any of the following symptoms, call your doctor immediately:
<ul>
<li>
blistering or peeling skin</li>
<li>
rash</li>
<li>
hives</li>
<li>
itching</li>
<li>
swelling of the eyes, face, lips, mouth, throat, or tongue</li>
<li>
difficulty breathing or swallowing</li>
<li>
hoarseness</li>
<li>
irregular, fast, or pounding heartbeat</li>
<li>
excessive tiredness</li>
<li>
dizziness</li>
<li>
lightheadedness</li>
<li>
muscle spasms</li>
<li>
uncontrollable shaking of a part of the body</li>
<li>
seizures</li></ul>Pantoprazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.People who take proton pump inhibitors such as pantoprazole may be more likely to fracture their wrists, hips, or spine than people who do not take one of these medications. The risk is highest in people who take high doses of one of these medications or take them for one year or longer. The risk may also be higher in people who are 50 years of age or older.People who take pantoprazole for a long time may develop weakening of the stomach lining and a low level of vitamin B12 in the blood. Talk to your doctor about the risks of taking pantoprazole.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p> <p></p> <p></p>
Precautions
Before taking pantoprazole, tell your doctor and pharmacist if you are allergic to pantoprazole, dexlansoprazole (Dexilant), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), rabeprazole (AcipHex), any other medications, or any of the ingredients in pantoprazole tablets or powder.Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: ampicillin (Principen), anticoagulants (blood thinners) such as warfarin (Coumadin), atazanavir (Reyataz), digoxin (Lanoxin, Lanoxicaps), diuretics ('water pills'), iron supplements, ketoconazole (Nizoral), and nelfinavir (Viracept). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had a low level of magnesium in your blood.
Overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Educational reference only — talk to a pharmacist or prescriber about Pantoprazole.