Paroxetine

Paroxetine tablets, suspension (liquid), and extended-release (long-acting) tablets are used to treat depression, panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks), and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). Paroxetine tablets and suspension are also used to treat obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), generalized anxiety disorder (GAD; excessive worrying that is difficult to control), and posttraumatic stress disorder (disturbing psychological symptoms that develop after a frightening experience). Paroxetine extended-release tablets are also used to treat premenstrual dysphoric disorder (PMDD, physical and psychological symptoms that occur before the onset of the menstrual period each month). Paroxetine is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.

Paroxetine comes as a tablet, a suspension (liquid), and a controlled-release (long-acting) tablet to take by mouth. It is usually taken once daily in the morning or evening, with or without food. You may want to take paroxetine with food to stop it from upsetting your stomach. Take paroxetine at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take paroxetine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid well before each use to mix the medication evenly. Swallow the extended-release and regular tablets whole; do not chew or crush them. Your doctor may start you on a low dose of paroxetine and gradually increase your dose, not more than once a week. Paroxetine controls your condition but does not cure it. It may take several weeks or longer before you feel the full benefit of paroxetine. Continue to take paroxetine even if you feel well. Do not stop taking paroxetine without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking paroxetine, you may experience withdrawal symptoms such as depression; mood changes; frenzied or abnormally excited mood; irritability; anxiety; confusion; dizziness; headache; tiredness; numbness or tingling in the arms, legs, hands, or feet; unusual dreams; difficulty falling asleep or staying asleep; nausea; or sweating. Tell your doctor if you experience any of these symptoms when your dose of paroxetine is decreased.

<p></p> <p></p> <p></p> <p>Paroxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

<ul>
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headache</li>
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dizziness</li>
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weakness</li>
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difficulty concentrating</li>
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nervousness</li>
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forgetfulness</li>
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confusion</li>
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sleepiness or feeling ''drugged''</li>
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nausea</li>
<li>
vomiting</li>
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diarrhea</li>
<li>
constipation</li>
<li>
gas</li>
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stomach pain</li>
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heartburn</li>
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changes in ability to taste food</li>
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decreased appetite</li>
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weight loss or gain</li>
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changes in sex drive or ability</li>
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dry mouth</li>
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sweating</li>
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yawning</li>
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sensitivity to light</li>
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runny nose</li>
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cough</li>
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lump or tightness in throat</li>
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pain in the back, muscles, joints, or anywhere in the body</li>
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muscle weakness or tightness</li>
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flushing</li>
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sore teeth and gums</li>
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unusual dreams</li>
<li>
painful or irregular menstruation</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

<ul>
<li>
blurred vision</li>
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seeing things or hearing voices that do not exist (hallucinating)</li>
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fainting</li>
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rapid, pounding, or irregular heartbeat</li>
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chest pain</li>
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difficulty breathing</li>
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seizure</li>
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fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness</li>
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abnormal bleeding or bruising</li>
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tiny red spots directly under the skin</li>
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sore throat, fever, chills, and other signs of infection</li>
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uncontrollable shaking of a part of the body</li>
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unsteady walking that may cause falling </li>
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sudden muscle twitching or jerking that you cannot control</li>
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numbness or tingling in your hands, feet, arms, or legs</li>
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difficult, frequent, or painful urination</li>
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swelling, itching, burning, or infection in the vagina</li>
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painful erection that lasts for hours</li>
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sudden nausea, vomiting, weakness, cramping, bloating, swelling, tightness in hands and feet, dizziness, headache and/or confusion</li>
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hives</li>
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skin rash</li>
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itching</li>
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swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs</li>
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hoarseness</li>
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difficulty breathing or swallowing</li>
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black and tarry stools</li>
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red blood in stools</li>
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bloody vomit</li>
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vomit that looks like coffee grounds</li></ul>Paroxetine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before taking paroxetine, tell your doctor and pharmacist if you are allergic to paroxetine or any other medications. tell your doctor if you are taking monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), if you have stopped taking them within the past 2 weeks, or if you are taking thioridazine or pimozide (Orap). Your doctor will probably tell you not to take paroxetine. If you stop taking paroxetine, you should wait at least 2 weeks before you start to take an MAO inhibitor. tell your doctor and pharmacist what other prescription and nonprescription medications and vitamins you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants ('mood elevators') such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); antihistamines; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin), and naproxen (Aleve, Naprosyn); atomoxetine (Straterra); atazanavir (Reyataz); bromocriptine (Parlodel); bupropion (Wellbutrin); buspirone (Buspar); celecoxib (Celebrex); chlorpromazine (Thorazine); cimetidine (Tagamet); clopidogrel (Plavix); codeine (found in many cough and pain medications); dexamethasone (Decadron); dextromethorphan (found in many cough medications); diazepam (Valium); dicloxacillin (Dynapen); digoxin (Lanoxin); dipyridamole (Persantine); diuretics ('water pills'); haloperidol (Haldol); isoniazid (INH, Nydrazid); lithium (Eskalith, Lithobid); medications for irregular heartbeat such as amiodarone (Cordarone, Pacerone), encainide (Enkaid), flecainide (Tambocor), mexiletine (Mexitil), moricizine (Ethmozine), propafenone (Rythmol), and quinidine (Quinidex); medications for mental illness and nausea; medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig);medications for seizures such as phenobarbital and phenytoin (Dilantin); meperidine (Demerol); methadone (Dolophine); metoclopramide (Reglan); metoprolol (Lopressor, Toprol XL); ondansetron (Zofran); other selective serotonin reuptake inhibitors such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), and sertraline (Zoloft); procyclidine (Kemadrin); propoxyphene (Darvon); propranolol (Inderal); ranitidine (Zantac); rifampin (Rifadin, Rimactane); risperidone (Risperdal); ritonavir (Norvir); sibutramine (Meridia); tamoxifen (Nolvadex); terbinafine (Lamisil); theophylline (Theobid, Theo-Dur); ticlopidine (Ticlid); timolol (Blocadren); tramadol (Ultram); trazodone (Desyrel); and venlafaxine (Effexor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan. tell your doctor if you use or have ever used street drugs or have overused prescription medications, if you have recently had a heart attack, and if you have or have ever had glaucoma (an eye disease); seizures; bleeding from your stomach or esophagus (tube that connects the mouth and stomach) or liver, kidney, or heart disease. you should know that paroxetine may make you drowsy and affect your judgment and thinking. Do not drive a car or operate machinery until you know how this medication affects you. ask your doctor about the safe use of alcoholic beverages while you are taking paroxetine.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include:

<ul>
<li>
drowsiness</li>
<li>
coma</li>
<li>
nausea</li>
<li>
uncontrollable shaking of a part of the body</li>
<li>
fast, pounding, irregular, or slow heartbeat</li>
<li>
confusion</li>
<li>
vomiting</li>
<li>
dizziness</li>
<li>
seizures</li>
<li>
fainting</li>
<li>
blurred vision</li>
<li>
extreme tiredness</li>
<li>
unusual bruising or bleeding</li>
<li>
lack of energy</li>
<li>
loss of appetite</li>
<li>
pain in the upper right part of the stomach</li>
<li>
flu-like symptoms</li>
<li>
yellowing of the skin and eyes</li>
<li>
aggressive behavior</li>
<li>
muscle pain, stiffness, or weakness</li>
<li>
sudden muscle twitching or jerking that you cannot control</li>
<li>
dark red or brown urine</li>
<li>
difficulty urinating</li>
<li>
diarrhea</li>
<li>
frenzied, abnormally excited mood</li>
<li>
sweating</li>
<li>
fever</li>
<li>
difficulty walking</li></ul>