Ribavirin

Ribavirin is used with another medication called an interferon to treat hepatitis C. Ribavirin is in a class of antiviral medications called nucleoside analogues. It works by stopping the virus that causes hepatitis C from spreading inside the body. It is not known if treatment that includes ribavirin and another medication cures hepatitis C infection, prevents liver damage that may be caused by hepatitis C, or prevents the spread of hepatitis C to other people.

Ribavirin comes as a tablet, a capsule and an oral solution (liquid) to take by mouth. It is usually taken twice a day, in the morning and the evening, for 24-48 weeks or longer. Take ribavirin tablets with food. Take ribavirin capsules and oral solution with food, unless your doctor tells you that you may take ribavirin with or without food. In that case, be sure to take the medication the same way every day. It is best to take ribavirin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ribavirin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid well before each use to mix the medication evenly. Be sure to wash the measuring spoon or cup after use each time you measure the liquid. Your doctor may decrease your dose or tell you to stop taking ribavirin for a short time if you develop side effects of the medication. Call your doctor if you are bothered by side effects of ribavirin. Do not decrease your dose or stop taking ribavirin unless your doctor tells you that you should.

<p></p> <p></p> <p></p> <p>Ribavirin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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cough</li>
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upset stomach</li>
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vomiting</li>
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diarrhea</li>
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constipation</li>
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heartburn</li>
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loss of appetite</li>
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weight loss</li>
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changes in ability to taste food</li>
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dry mouth</li>
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difficulty concentrating</li>
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difficulty falling asleep or staying asleep</li>
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memory loss</li>
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rash</li>
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dry, irritated, or itchy skin</li>
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sweating</li>
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painful or irregular menstruation (period)</li>
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muscle or bone pain</li>
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hair loss</li></ul></p> <p></p> <p>Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, or those listed in the IMPORTANT WARNING section, call your doctor immediately:

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hives</li>
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swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs</li>
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hoarseness</li>
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difficulty swallowing or breathing</li>
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pain in the stomach or lower back </li>
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bloody diarrhea</li>
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bright red blood in stools</li>
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black, tarry stools</li>
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unusual bleeding or bruising</li>
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vision changes</li>
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fever, chills, and other signs of infection</li>
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depression</li>
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thinking about hurting or killing yourself</li>
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mood changes</li>
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excessive worry</li>
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irritability</li>
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starting to use street drugs or alcohol again if you used these substances in the past</li>
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worsening of psoriasis that you had before you started to take ribavirin </li>
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intolerance to cold</li></ul>Ribavirin may slow growth and weight gain in children. Talk to your child's doctor about the risks of giving this medication to your child.Ribavirin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before taking ribavirin, tell your doctor and pharmacist if you are allergic to ribavirin or any other medications. If you are taking ribavirin tablets, tell your doctor if you are allergic to corn. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: medications for anxiety, depression,or any other mental illness; medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as didanosine (Videx), stavudine (Zerit), and zidovudine (Retrovir); and medications that supress the immune system such as cancer chemotherapy, cyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Prograf). If you are taking ribavirin capsules, tell your doctor if you are taking antacids. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you drink or have ever drunk large amounts of alcohol, if you use or have ever used street drugs, if you have ever thought about killing yourself or planned or tried to do so, and if you have ever had an organ transplant. Also tell your doctor if you have or have ever had a mental illness such as depression, anxiety, or psychosis (loss of contact with reality); cancer; psoriasis (an inherited skin condition); HIV or AIDS; diabetes; sarcoidosis (a condition in which abnormal tissue grows in parts of the body such as the lungs); Gilbert's syndrome (a mild liver condition that may cause yellowing of the skin or eyes); gout (a type of arthritis caused by crystals deposited in the joints); any type of liver disease other than hepatitis C;or thyroid, kidney, pancreas,eye, or lung disease. tell your doctor if you have ever taken any medication to treat hepatitis C. Be sure that your doctor has your complete medical records and knows how well you responded to other treatments for hepatitis C. you should know that ribavirin may make you drowsy, dizzy, or confused. Do not drive a car or operate machinery until you know how this medication affects you. do not drink alcoholic beverages while you are taking ribavirin. Alcohol can make your liver disease worse.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.