Sertraline

Sertraline is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks), posttraumatic stress disorder (disturbing psychological symptoms that develop after a frightening experience), and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). It is also used to relieve the symptoms of premenstrual dysphoric disorder, including mood swings, irritability, bloating, and breast tenderness. Sertraline is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amounts of serotonin, a natural substance in the brain that helps maintain mental balance.

Sertraline comes as a tablet and a concentrate (liquid) to take by mouth. It is usually taken once daily in the morning or evening. To treat premenstrual dysphoric disorder, sertraline is taken once a day, either every day of the month or on certain days of the month. Take sertraline at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sertraline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Sertraline concentrate must be diluted before use. Immediately before taking it, use the provided dropper to remove the amount of concentrate your doctor has told you to take. Mix the concentrate with 4 ounces (1/2 cup [120 milliliters]) of water, ginger ale, lemon or lime soda, lemonade, or orange juice. Do not mix the concentrate with any liquids other than the ones listed. Drink immediately. Your doctor may start you on a low dose of sertraline and gradually increase your dose, not more than once a week. It may take a few weeks or longer before you feel the full benefit of sertraline. Continue to take sertraline even if you feel well. Do not stop taking sertraline without talking to your doctor.

<p></p> <p></p> <p></p> <p>Sertraline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

<ul>
<li>
nausea</li>
<li>
diarrhea</li>
<li>
constipation</li>
<li>
vomiting</li>
<li>
dry mouth</li>
<li>
gas or bloating</li>
<li>
loss of appetite</li>
<li>
weight changes</li>
<li>
drowsiness</li>
<li>
dizziness</li>
<li>
excessive tiredness</li>
<li>
headache</li>
<li>
pain, burning, or tingling in the hands or feet</li>
<li>
nervousness</li>
<li>
uncontrollable shaking of a part of the body</li>
<li>
sore throat</li>
<li>
changes in sex drive or ability</li>
<li>
excessive sweating</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

<ul>
<li>
blurred vision</li>
<li>
seizures</li>
<li>
fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness</li>
<li>
abnormal bleeding or bruising</li>
<li>
hallucinating (seeing things or hearing voices that do not exist)</li></ul>Sertraline may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Before taking sertraline, tell your doctor and pharmacist if you are allergic to sertraline or any other medications. Before taking sertraline liquid concentrate, tell your doctor if you are allergic to latex. tell your doctor if you are taking monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or have stopped taking them within the past 2 weeks, or if you are taking pimozide (Orap). Your doctor will probably tell you not to take sertraline. If you stop taking sertraline, you should wait at least 2 weeks before you start to take an MAO inhibitor. do not take disulfiram (Antabuse) while taking sertraline concentrate. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants ('mood elevators') such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); cimetidine (Tagamet); diazepam (Valium); digoxin (Lanoxin); lithium (Eskalith, Lithobid); medications for anxiety, mental illness, Parkinson's disease, and seizures; medications for irregular heartbeat such as flecainide (Tambocor) and propafenone (Rythmol); oral medications for diabetes such as tolbutamide (Orinase); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); sedatives; sibutramine (Meridia); sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have recently had a heart attack and if you have or have ever had seizures or liver or heart disease. you should know that sertraline may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. ask your doctor about the safe use of alcoholic beverages while you are taking sertraline.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include:

<ul>
<li>
hair loss</li>
<li>
changes in sex drive or ability</li>
<li>
drowsiness</li>
<li>
excessive tiredness</li>
<li>
difficulty falling asleep or staying asleep</li>
<li>
diarrhea</li>
<li>
vomiting</li>
<li>
rapid, pounding, or irregular heartbeat</li>
<li>
nausea</li>
<li>
dizziness</li>
<li>
excitement</li>
<li>
uncontrollable shaking of a part of the body</li>
<li>
seizures</li>
<li>
hallucinating (hearing voices or seeing things that do not exist)</li>
<li>
unconsciousness</li>
<li>
fainting</li></ul>