Silodosin

Why this is used

Silodosin is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia; BPH), which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. Silodosin is in a class of medications called alpha-blockers. It relieves the symptoms of BPH by relaxing the muscles of the bladder and prostate.

How to take it

Silodosin comes as a capsule to take by mouth. It is usually taken with food once a day. Do not take silodosin on an empty stomach. Take silodosin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take silodosin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Silodosin controls the symptoms of BPH but does not cure it. Continue to take silodosin even if you feel well. Do not stop taking silodosin without talking to your doctor.

Side effects

<p></p> <p></p> <p></p> <p>Silodosin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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orgasm with little or no semen (fluid)</li>
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diarrhea</li>
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dizziness</li>
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low blood pressure</li>
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stuffy or runny nose</li></ul></p> <p></p> <p>Some side effects can be serious. If you experience any of these symptoms , call your doctor immediately:

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painful erection of the penis that lasts for several hours</li></ul>Silodosin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Precautions

Before taking silodosin, tell your doctor and pharmacist if you are allergic to silodosin or any other medications. tell your doctor if you are taking antifungals such as ketoconazole (Nizoral) and itraconazole (Sporanox); clarithromycin (Biaxin, in Prevpac); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase); nefazodone; telithromycin (Ketek). Your doctor will probably tell you not to take silodosin. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cyclosporine (Neoral, Sandimmune); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); fluconazole (Diflucan); medications for high blood pressure;other alpha blockers such as doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), and tamsulosin (Flomax); and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with silodosin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. tell your doctor if you have kidney or liver disease. Your doctor will probably tell you not to take silodosin. tell your doctor if you have or have ever had low blood pressure. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking silodosin. If you need to have eye surgery at any time during or after your treatment, be sure to tell your doctor that you are taking or have taken silodosin. you should know that silodosin may make you drowsy or dizzy, especially when you first start taking it. Do not drive a car or operate machinery until you know how this medication affects you. you should know that silodosin may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking silodosin. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. If you experience these symptoms, sit or lie down. If these symptoms do not improve, call your doctor.

Overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include:

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dizziness</li>
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fainting</li>
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lightheadedness</li>
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blurred vision</li></ul>
Educational reference only — talk to a pharmacist or prescriber about Silodosin.