Tinidazole

Why this is used

Tinidazole is used to treat trichomoniasis (a sexually transmitted disease that can affect men and women), giardiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps), and amebiasis (an infection of the intestine that can cause diarrhea, gas, and stomach cramps and can spread to other organs such as the liver). Tinidazole is in a class of medications called antiprotozoal agents. It works by killing the organisms that can cause infection.

How to take it

Tinidazole comes as a suspension (liquid) prepared by the pharmacist and a tablet to take by mouth. It is usually taken with food as a single dose or once a day for 3 to 5 days. To help you remember to take tinidazole (if you are to take it for more than one day), take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tinidazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid well before each use to mix the medication evenly. Take tinidazole until you finish the prescription, even if you feel better. If you stop taking tinidazole too soon or skip doses, your infection may not be completely cured and bacteria may become resistant to antibiotics

Side effects

<p></p> <p></p> <p></p> <p>Tinidazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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sharp, unpleasant metallic taste</li>
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upset stomach</li>
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vomiting</li>
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loss of appetite</li>
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constipation</li>
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stomach pain or cramps</li>
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headache</li>
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tiredness or weakness</li>
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dizziness</li></ul></p> <p></p> <p>Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

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seizures</li>
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numbness or tingling of hands or feet</li>
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rash</li>
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hives</li>
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swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs</li>
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hoarseness</li>
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difficulty swallowing or breathing</li></ul>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at <a href='http://www.fda.gov/Safety/MedWatch'>http://www.fda.gov/Safety/MedWatch</a>] or by phone [1-800-332-1088].</p>

Precautions

Before taking tinidazole, tell your doctor and pharmacist if you are allergic to tinidazole, metronidazole (Flagyl), or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); carbamazepine (Tegretol); cimetidine (Tagamet); clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); danazol (Danocrine); delavirdine (Rescriptor); dexamethasone (Decadron); diltiazem (Cardizem, Dilacor; Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); ethosuximide (Zarontin); fluorouracil (Adrucil ); fluoxetine (Prozac, Sarafem); fluvoxamine (Luvox); fosphenytoin (Cerebyx); HIV protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir); isoniazid (INH, Nydrazid); lithium (Lithobid); metronidazole (Flagyl); nefazodone (Serzone); oral contraceptives (birth control pills); oxytetracycline (Terramycin); phenobarbital (Luminal, Solfoton); phenytoin (Dilantin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); tacrolimus (Prograf); troglitazone (Rezulin); troleandomycin (TAO); verapamil (Calan, Covera, Isoptin, Verelan); and zafirlukast (Accolate). Also tell your doctor if you are taking disulfiram (Antabuse) or have stopped taking it within the past 2 weeks. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. if you are taking cholestyramine (Questran), you should not take it at the same time that you take tinidazole. Ask your doctor or pharmacist how to space doses of these medications. tell your doctor if you have a yeast infection now; if you are being treated with dialysis (mechanical removal of waste in patients with kidney failure); or if you have or have ever had seizures or nervous system, blood, or liver disease. know that you should not drink alcohol while you are taking this medication and for 3 days afterwards. Alcohol may cause an upset stomach, vomiting, stomach cramps, headaches, sweating, and flushing (redness of the face).

Overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Educational reference only — talk to a pharmacist or prescriber about Tinidazole.