Serotonin syndrome (severe medication reaction)
About Serotonin syndrome (severe medication reaction)
A reaction to medications that have serotonin activity ( serotonin is a brain hormone or `neurotransmitter`). This reaction usually occurs when several medications are taken. These medications include: antidepressants, triptans for migraines, pain medications, anti-nausea medications, lithium, over-the-counter cold medications. Patients can experience restlessness, rapid heartbeat, fever, muscle rigidity, altered mental status and seizures.Symptoms
Restlessness, hallucinations, incoordination, fast heartbeat, rapid changes in blood pressure, fever, overactive reflexes, nausea, vomiting, diarrhea, headache, muscle twitching, weakness, abdominal pain, anxiety, seizures, coma.Tests & Diagnostics
A history and physical exam will be performed. Tests to rule out other causes of the symptoms may be done.Common tests: BHCG, Complete blood count (CBC), Comprehensive metabolic panel (CMP), CT Scan, EKG, Urinalysis (UA), X-ray.
Prescription medications
Conventional treatment summary
Therapy includes supporting the vital signs and withdrawing the medications that caused the syndrome. Some medications may help: cyproheptadine (Periactin), benzodiazepines (Valium, Ativan), and/or blood pressure medications. Consider calling the National Poison Control Phone Number for further information or assistance: 1-800-222-1222.Medical specialties
Medical Toxicology
This page is educational content, not medical advice. Always consult a qualified clinician for diagnosis and treatment of Serotonin syndrome (severe medication reaction).