Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Bile acid

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Bile acid

The Cochrane Hepato-Biliary Group 2 Type 2 diabetes mellitus (T2DM) is a severe metabolic diseas 1 PI3K Gene Mutation|AKT Gene Mutation|MTOR Gene Mutation|Canc 1 Type 2 diabetes 1 Obesity|Healthy 1 The Cochrane Metabolic and Endocrine Disorders Group 1 Obesity is a growing global issue and diet plays an inevitab 1 Nonalcoholic fatty liver disease has become the most common 1 Liver cirrhosis is the end stage liver disease resulting fro 1 Intrahepatic cholestasis of pregnancy is a gestation-specifi 1 Intrahepatic cholestasis of pregnancy (ICP) is a multifactor 1 Intrahepatic cholestasis of pregnancy (also known as obstetr 1

📋 Sample Trials

NCT05314374

Effect of Bile Acids on Satiety, Cell Function and Body Weight in Patients With Obesity and Abnormal Satiety Phenotype

Enrolling_By_Invitation · Phase 1

NCT05571670

Bile Acids in Acute Insulin Resistance

Recruiting

📊 Sample Meta-Analyses

CRD42012001911

A systematic review and economic evaluation of SeHCAT (Tauroselcholic [75Selenium] acid) for the investigation of bile acid malabsorption (BAM) and measurement of bile acid pool loss

CRD42012002552

Effect of bile acid sequestrants on glycaemic control: a systematic review and meta-analysis of randomised controlled trials

Type 2 diabetes mellitus (T2DM) is a severe metabolic disease characterised by r

CRD42015032326

Bile acid sequestrants in inflammatory bowel disease

Inflammatory bowel disease

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Bile acid

⚗️ Identity

Name

Bile acid

Aliases / Synonyms

Bile salt; CHEBI:22868; Gallensaeure; Gallensaeuren; 5beta-bile acid; 5beta-bile acids; Acid, Bile; CHEBI:3098; CHEBI:138366

🧪 Chemistry

Molecular Weight

408.5790

LogP

3.4487

Drug-likeness

0.571

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(CCC(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C

Isomeric SMILES

CC(CCC(=O)O)C1CCC2C1([C@H](CC3C2[C@@H](C[C@H]4C3(CC[C@H](C4)O)C)O)O)C

InChIKey

BHQCQFFYRZLCQQ-UMZBRFQRSA-N

InChI

InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13?,14-,15+,16?,17?,18?,19+,20-,22?,23?,24?/m0/s1

🔗 External References

HERB DB

HBIN018507 ↗

PubChem CID

439520 ↗

TCMID

23866

🔍 Raw view — every non-empty column on this row (27 fields)

name

Bile acid

common names

Bile salt; CHEBI:22868; Gallensaeure; Gallensaeuren; 5beta-bile acid; 5beta-bile acids; Acid, Bile; CHEBI:3098; CHEBI:138366

herb ingredient id

HBIN018507

canonical smiles

CC(CCC(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C

isomeric smiles

CC(CCC(=O)O)C1CCC2C1([C@H](CC3C2[C@@H](C[C@H]4C3(CC[C@H](C4)O)C)O)O)C

inchi

InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13?,14-,15+,16?,17?,18?,19+,20-,22?,23?,24?/m0/s1

inchikey

BHQCQFFYRZLCQQ-UMZBRFQRSA-N

mol wt

408.5790

num h acceptors

num h donors

mol logp

3.4487

num rotatable bonds

drug likeness

0.571

tcmid ingredient id

23866

pubchem cid

439520

📋 Clinical Trials

2 · subject of clinical study

NCT05314374 Effect of Bile Acids on Satiety, Cell Function and Body Weight in Patients With

→ Obesity|Healthy

NCT05571670 Bile Acids in Acute Insulin Resistance

→ PI3K Gene Mutation|AKT Gene Mutation|MTOR Gene Mut

📊 Meta-Analyses

12 · systematic review

CRD42012001911 A systematic review and economic evaluation of SeHCAT (Tauroselcholic [75Seleniu

CRD42012002552 Effect of bile acid sequestrants on glycaemic control: a systematic review and m

→ Type 2 diabetes mellitus (T2DM) is a severe metabo

CRD42015032326 Bile acid sequestrants in inflammatory bowel disease

→ Inflammatory bowel disease

CRD42016045492 Bile acid derivatives for people with primary sclerosing cholangitis [Cochrane P

→ The Cochrane Hepato-Biliary Group

CRD42016045493 Bile acid derivatives for people with primary biliary cholangitis [Cochrane Prot

→ The Cochrane Hepato-Biliary Group

CRD42016045966 Adjunctive bile acid sequestrant therapy for hyperthyroidism in adults [Cochrane

→ The Cochrane Metabolic and Endocrine Disorders Gro

CRD42017056590 Total serum bile acids or serum bile acid profile, or both, for the diagnosis of

→ Intrahepatic cholestasis of pregnancy (also known

CRD42017083002 Total serum bile acids or serum bile acid profile, or both, for the diagnosis of

→ Intrahepatic cholestasis of pregnancy is a gestati

CRD42018111642 Obstetric outcomes as assessed by bile acid levels associated with intrahepatic

→ Intrahepatic cholestasis of pregnancy (ICP) is a m

CRD42018115768 Targeting bile acid metabolism in obesity reduction: a systematic review and met

→ Obesity is a growing global issue and diet plays a

CRD42021238193 Predictive value of liver cirrhosis using metabolite biomarkers of bile acid in

→ Liver cirrhosis is the end stage liver disease res

CRD42022345481 Correlation between serum bile acid and nonalcoholic fatty liver disease: A Syst

→ Nonalcoholic fatty liver disease has become the mo

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables