Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Taxol

Open on HERB 2.0 ↗

1,256

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Taxol

Breast Cancer 143 Lung Cancer 63 Non-small Cell Lung Cancer 38 Ovarian Cancer 34 Metastatic Breast Cancer 27 Unspecified Adult Solid Tumor, Protocol Specific 24 Head and Neck Cancer 23 Esophageal Cancer 19 Carcinoma, Non-Small-Cell Lung 17 Prostate Cancer 15 Neoplasms 14 Endometrial Cancer 13

📋 Sample Trials

NCT02311907

Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

Completed · Phase 3

NCT00091377

Phenoxodiol Combined With Either Cisplatin or Paclitaxel in Patients With Recurrent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer

Completed · Phase 1|Phase 2

NCT03410030

Trial of Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM)

Completed · Phase 1|Phase 2

📊 Sample Meta-Analyses

CRD42020163503

The optimal Chinese herbal injections for use with taxol plus cisplatin for treating non-small cell lung cancer: a systematic review and Bayesian network meta-analysis

non-small cell lung cancer

CRD42021228753

The efficacy and safety of docetaxel/paclitaxel, cisplatin, and 5-fluorouracil for gastric cancer: a systematic review and meta-analysis

Gastric cancer

CRD42013003555

Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for the treatment of recurrent ovarian cancer

This review will focus on people who have recurrent or refractory ovarian cancer

📚 Sample References

PMID 31906029

Activation of PERK Contributes to Apoptosis and G2/M Arrest by Microtubule Disruptors in Human Colorectal Carcinoma Cells ‡

Cancers (Basel) · 2019

PMID 30322956

Choosing the Best Chemotherapy Agent to Boost Immune Checkpoint Inhibition Activity

Cancer Res · 2018

PMID 28589243

RNAi targeting STMN alleviates the resistance to taxol and collectively contributes to down regulate the malignancy of NSCLC cells in vitro and in vivo

Cell Biol Toxicol · 2018

⚗️ All Ingredient data fields for Taxol

⚗️ Identity

Name

Taxol

Aliases / Synonyms

33069-62-4; P88XT4IS4D; Paclitaxel; Taxol A; Yewtaxan; Genaxol; Plaxicel; Abraxane; Ebetaxel

🧪 Chemistry

Molecular Weight

853.9180

LogP

3.7357

Drug-likeness

0.13

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

Isomeric SMILES

CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

InChIKey

RCINICONZNJXQF-MZXODVADSA-N

InChI

InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

🔗 External References

HERB DB

HBIN045705 ↗

PubChem CID

36314 ↗

CAS Number

33069-62-4 ↗

NPASS

NPC208553

HIT

C0281

TCMID

20795

TCM-ID

612

🔍 Raw view — every non-empty column on this row (31 fields)

name

Taxol

common names

33069-62-4; P88XT4IS4D; Paclitaxel; Taxol A; Yewtaxan; Genaxol; Plaxicel; Abraxane; Ebetaxel

herb ingredient id

HBIN045705

canonical smiles

CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

isomeric smiles

CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

inchi

inchikey

RCINICONZNJXQF-MZXODVADSA-N

mol wt

853.9180

num h acceptors

num h donors

mol logp

3.7357

num rotatable bonds

drug likeness

0.13

cas id

33069-62-4

tcmid ingredient id

20795

tcm id ingredient id

612

pubchem cid

36314

npass id

NPC208553

hit id

C0281

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Adenocarcinoma

group

Non-Small Cell Lung Carcinoma

disease

Squamous Cell Carcinoma

disease

Coronary Heart Disease

syndrome

Endometrial Neoplasms

group

Genital Neoplasms, Female

group

Head And Neck Neoplasms

Myocardial Infarction

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT02311907 Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carbopl

→ Chemotherapeutic Agent Toxicity|Neuropathy|Neuroto

NCT00091377 Phenoxodiol Combined With Either Cisplatin or Paclitaxel in Patients With Recurr

→ Fallopian Tube Cancer|Ovarian Cancer|Primary Perit

NCT03410030 Trial of Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin

→ Pancreatic Cancer|Pancreas Cancer|Pancreatic Adeno

NCT00001272 A Phase I Study of Taxol, Cisplatin, Cyclophosphamide and Granulocyte Colony-Sti

→ Ovarian Neoplasms

NCT00001383 A Phase I Study of Infusional Paclitaxel With the P-Glycoprotein Antagonist PSC

→ Breast Cancer|Cancer|Carcinoma, Renal Cell|Lymphom

NCT00001384 A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Gran

→ Breast Cancer|Breast Neoplasms

NCT00001387 Phase I and Pharmacokinetic Trial of Paclitaxel (Taxol) Given as a 3-Hour Infusi

→ Neoplasms

NCT00001426 A Multi-Institutional Phase II Study of Cyclophosphamide, Paclitaxel, Cisplatin

→ Ovarian Neoplasm

NCT00001442 A Pilot Study of Paclitaxel With Radiation Therapy for Locally Advanced Head and

→ Head and Neck Neoplasm|Squamous Cell Carcinoma

NCT00001450 Phase II Trial of a 96-Hour Continuous Infusion of Paclitaxel Followed by Cispla

→ Carcinoma, Non-Small-Cell Lung|Lung Neoplasms

NCT00001498 A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dos

→ Breast Cancer|Breast Neoplasms

NCT00001499 Phase II Neoadjuvant Trial of a Continuous Infusion of Paclitaxel Plus Cisplatin

→ Carcinoma, Non-Small-Cell Lung|Lung Neoplasms

📊 Meta-Analyses

12 · systematic review

CRD42020163503 The optimal Chinese herbal injections for use with taxol plus cisplatin for trea

→ non-small cell lung cancer

CRD42021228753 The efficacy and safety of docetaxel/paclitaxel, cisplatin, and 5-fluorouracil f

→ Gastric cancer

CRD42013003555 Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedi

→ This review will focus on people who have recurren

CRD42016043848 Weekly versus tri-weekly paclitaxel with carboplatin for first-line treatment in

→ The Cochrane Gynaecological Cancer Group

CRD42017082923 Weekly versus tri-weekly paclitaxel with carboplatin for first-line treatment in

→ The Cochrane Gynaecological, Neuro-oncology and Or

CRD42018094170 <div>A network meta-analysis of taxanes and their formulations in chemotherapy f

→ Cancer; Anti-tumor drugs.

CRD42018099447 Risk of death following paclitaxel-coated stents and balloons in the femoropopli

→ Risk of death following endovascular revasculariza

CRD42018114416 Neoadjuvant chemotherapy with nab-paclitaxel for the treatment of women with tri

→ Breast cancer is the most common type of cancer af

CRD42019117912 Nanoparticle albumin-bound paclitaxel vs solvent-based paclitaxel in breast canc

→ Breast cancer. Efficacy and side effects in women.

CRD42019118085 The efficacy and safety of nab-paclitaxel compared with conventional paclitaxel

→ Breast cancer. Efficacy and side effects in women.

CRD42019127784 Efficacy and safety of paclitaxel liposome versus paclitaxel in the treatment of

→ Esophageal cancer, chemotherapy, paclitaxel liposo

CRD42019135326 NeoGNP - a systematic review and meta-analysis about efficacy and safety of neoa

→ Locally advanced or Borderline resectable pancreat

📚 PubMed References

12 · cited research

PMID 31906029 Activation of PERK Contributes to Apoptosis and G2/M Arrest by Microtubule Disru

Cancers (Basel)

PMID 30322956 Choosing the Best Chemotherapy Agent to Boost Immune Checkpoint Inhibition Activ

Cancer Res

PMID 28589243 RNAi targeting STMN alleviates the resistance to taxol and collectively contribu

Cell Biol Toxicol

PMID 24080340 Identification and analysis of CD133(+) melanoma stem-like cells conferring resi

Cancer Lett

PMID 23726937 Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in

J Pain

PMID 23681233 Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: r

Cell Death Dis

PMID 21984124 Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-reg

J Pathol

PMID 21525288 Axon formation in neocortical neurons depends on stage-specific regulation of mi

J Neurosci

PMID 31420851 LIN9 confers paclitaxel resistance in triple negative breast cancer cells by upr

Sci China Life Sci

PMID 31969555 Blockade of IL-6 signaling prevents paclitaxel-induced neuropathy in C57Bl/6 mic

Cell Death Dis

PMID 32064933 KANK1 regulates paclitaxel resistance in lung adenocarcinoma A549 cells

Artif Cells Nanomed Biotechnol

PMID 32068666 Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy

Pain

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables