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Disease
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Evidence
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trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
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⚗️ Ingredient

L-tetrahydropalmatine

Open on HERB 2.0 ↗
2
Clinical Trials
0
Meta-Analyses
1
PubMed References
Top Conditions Studied with L-tetrahydropalmatine
Schizophrenia 1 Cocaine Use 1
📋 Sample Trials
NCT01631383
Pharmacokinetic and Safety Evaluation of L-tetrahydropalmatine (l-THP) With Cocaine Exposure in People With a History of Cocaine Use
Completed · Phase 1
NCT02118610
Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity
Completed
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 31725199
l-tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK-TRAF6 interactions and inhibiting NF-κB and MAPK pathways
J Cell Mol Med · 2020
⚗️ All Ingredient data fields for L-tetrahydropalmatine
⚗️ Identity
Name
L-tetrahydropalmatine
Aliases / Synonyms
Rotundine; tetrahydropalmatine; 483-14-7; (-)-Tetrahydropalmatine; Gindarine; Hyndarine; (S)-Tetrahydropalmatine; Caseanine; (-)-Corydalis B
🧪 Chemistry
Molecular Weight
355.4340
LogP
3.3765
Drug-likeness
0.841
Oral Bioavailability
73.9370
H-Bond Acceptors
5
Rotatable Bonds
4
🔬 Structures
Canonical SMILES
COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
Isomeric SMILES
COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
InChIKey
AEQDJSLRWYMAQI-KRWDZBQOSA-N
InChI
InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1
🔗 External References
HERB DB
HBIN029807 ↗
PubChem CID
72301 ↗
CAS Number
84-38-8 ↗
NPASS
NPC210437
HIT
C0439
TCMID
35117; 23384
TCMSP
MOL004071
TCM-ID
9097
🔍 Raw view — every non-empty column on this row (33 fields)
name
L-tetrahydropalmatine
common names
Rotundine; tetrahydropalmatine; 483-14-7; (-)-Tetrahydropalmatine; Gindarine; Hyndarine; (S)-Tetrahydropalmatine; Caseanine; (-)-Corydalis B
herb ingredient id
HBIN029807
canonical smiles
COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
isomeric smiles
COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
inchi
InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1
inchikey
AEQDJSLRWYMAQI-KRWDZBQOSA-N
mol wt
355.4340
num h acceptors
5
num h donors
0
mol logp
3.3765
num rotatable bonds
4
drug likeness
0.841
ob score
73.9370
cas id
84-38-8
tcmid ingredient id
35117; 23384
tcmsp ingredient id
MOL004071
tcm id ingredient id
9097
pubchem cid
72301
npass id
NPC210437
hit id
C0439

🏥 Linked Health Topics

2 · studied for these conditions (text bridge)
Schizophrenia
disease
Cocaine Use
disease

📋 Clinical Trials

2 · subject of clinical study
NCT01631383 Pharmacokinetic and Safety Evaluation of L-tetrahydropalmatine (l-THP) With Coca
→ Cocaine Use
NCT02118610 Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine
→ Schizophrenia

📚 PubMed References

1 · cited research
PMID 31725199 l-tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blo
J Cell Mol Med
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables