Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Tetrodotoxin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Tetrodotoxin

Pain|Cancer 2 Healthy 1 Chemotherapy-induced Neuropathic Pain|Chemotherapy-induced P 1 TQT Study 1

📋 Sample Trials

NCT00725114

Safety & Efficacy Study of Subcutaneous Tetrodotoxin for Moderate to Severe Inadequately Controlled Cancer-related Pain

Completed · Phase 3

NCT00726011

Tetrodotoxin Open-label Efficacy and Safety Continuation Study

Completed · Phase 3

NCT01527734

Comparison Study of Liquid and Lyophilized Formulations of Subcutaneous Tetrodotoxin (TTX) in Healthy Volunteers

Completed · Phase 1

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 29177486

Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myenteric Neuronal Mechanisms in Humans

J Clin Endocrinol Metab · 2018

PMID 29097069

Dose-related ethanol intake, Cx43 and Nav1.5 remodeling: Exploring insights of altered ventricular conduction and QRS fragmentation in excessive alcohol users

J Mol Cell Cardiol · 2018

PMID 28832970

Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Nav 1.1 to Nav 1.7)

Br J Pharmacol · 2017

⚗️ All Ingredient data fields for Tetrodotoxin

⚗️ Identity

Name

Tetrodotoxin

Aliases / Synonyms

Spheroidine; Tarichatoxin; Tetrodotoxine; 4368-28-9; Babylonia japonica toxin 1; Tetrodoxin; Tectin; BJT 1; Maculotoxin

🧪 Chemistry

Molecular Weight

319.2700

LogP

-5.5198

Drug-likeness

0.231

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(C1(C2C3C(N=C(NC34C(C1OC(C4O)(O2)O)O)N)O)O)O

Isomeric SMILES

C([C@@]1([C@H]2[C@@H]3[C@H](N=C(N[C@@]34[C@@H]([C@@H]1O[C@]([C@H]4O)(O2)O)O)N)O)O)O

InChIKey

CFMYXEVWODSLAX-QOZOJKKESA-N

InChI

InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1

🔗 External References

HERB DB

HBIN046126 ↗

PubChem CID

11174599 ↗

DrugBank

DB05232 ↗

TCMID

21195

🔍 Raw view — every non-empty column on this row (28 fields)

name

Tetrodotoxin

common names

Spheroidine; Tarichatoxin; Tetrodotoxine; 4368-28-9; Babylonia japonica toxin 1; Tetrodoxin; Tectin; BJT 1; Maculotoxin

herb ingredient id

HBIN046126

canonical smiles

C(C1(C2C3C(N=C(NC34C(C1OC(C4O)(O2)O)O)N)O)O)O

isomeric smiles

C([C@@]1([C@H]2[C@@H]3[C@H](N=C(N[C@@]34[C@@H]([C@@H]1O[C@]([C@H]4O)(O2)O)O)N)O)O)O

inchi

InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3-,4-,5+,6-,7+,9+,10-,11+/m1/s1

inchikey

CFMYXEVWODSLAX-QOZOJKKESA-N

mol wt

319.2700

num h acceptors

num h donors

mol logp

-5.5198

num rotatable bonds

drug likeness

0.231

tcmid ingredient id

21195

pubchem cid

11174599

drugbank id

DB05232

📋 Clinical Trials

5 · subject of clinical study

NCT00725114 Safety & Efficacy Study of Subcutaneous Tetrodotoxin for Moderate to Severe Inad

→ Pain|Cancer

NCT00726011 Tetrodotoxin Open-label Efficacy and Safety Continuation Study

→ Pain|Cancer

NCT01527734 Comparison Study of Liquid and Lyophilized Formulations of Subcutaneous Tetrodot

→ Healthy

NCT04083833 A Phase 1, Single Ascending Dose, Randomized, Double-Blind, Placebo and Positive

→ TQT Study

NCT05359133 A Randomized, Double-Blind, Placebo Controlled, Multicenter, Efficacy and Safety

→ Chemotherapy-induced Neuropathic Pain|Chemotherapy

📚 PubMed References

9 · cited research

PMID 29177486 Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myen

J Clin Endocrinol Metab

PMID 29097069 Dose-related ethanol intake, Cx43 and Nav1.5 remodeling: Exploring insights of a

J Mol Cell Cardiol

PMID 28832970 Differential binding of tetrodotoxin and its derivatives to voltage-sensitive so

Br J Pharmacol

PMID 26106219 DNA methylation regulates neuronal glutamatergic synaptic scaling

Sci Signal

PMID 25135948 Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium chan

Mol Biol Evol

PMID 24719357 Pancreatic β-cell Na+ channels control global Ca2+ signaling and oxidative metab

FASEB J

PMID 24285882 Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+

J Neurosci

PMID 23170805 Angiotensin II contractile effects in mouse colon: role for pre- and post-juncti

Acta Physiol (Oxf)

PMID 22723692 Activity-dependent regulation of inhibition via GAD67

J Neurosci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables