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A Short History of Herbal Medicine

A short, respectful history of herbal medicine, from early written plant records in Egypt, China and Greece to monastery gardens and the isolation of plant compounds in the 1800s.

Content last updated . This page has not been medically reviewed.

Safety first. Natural products can cause side effects and interact with medicines. Read herb safety and interactions before you use anything on this page.

Why history is not proof

Every culture used plants for health, and written records tell us a great deal about what people believed. They do not tell us whether a plant works. This page is a short overview of how plant knowledge was recorded and passed on. It is traditional and historical information, kept separate from research findings, and it does not recommend any herb.

The main source for this page is a historical review of medicinal plants' usage in a pharmacognosy journal.[1] Pharmacognosy is the study of medicines from natural sources. Dates for very early texts are given by that review and are approximate.

Early written records

  • China. The review says the Chinese book on roots and grasses "Pen T'Sao" was written by Emperor Shen Nung circa 2500 BC and treats 365 drugs (dried parts of medicinal plants).[1] We give the review's date as stated and have not checked it against other sources.
  • Egypt. The Ebers Papyrus, written circa 1550 BC, is described as a collection of 800 proscriptions referring to 700 plant species.[1]
  • Greece and Rome. Dioscorides wrote "De Materia Medica" circa 77 AD, a work the review says was translated many times.[1] The review notes that Dioscorides pointed to the possibility of forgery of drugs,[1] an early record of the adulteration problem that still matters. See adulteration and substitution of herbs.

Old texts also contained errors. The review describes a belief about camomile recorded by Dioscorides as an untrue belief that was later embraced by both the Romans and the Arabs.[1] That is one reason historical use is read as a record of belief, not as evidence.

Many traditions, not one

The review gives most of its attention to Mediterranean, European and Arab sources, plus the early Chinese text. It does not cover other traditions in depth, so we link to separate pages:

Middle Ages and the exchange of plants

In the Middle Ages, the review says the skills of healing, cultivation of medicinal plants, and preparation of drugs moved to monasteries.[1] It also says the Arabs introduced numerous new plants in pharmacotherapy, mostly from India.[1] After European voyages across the Atlantic, the review says materia medica was enriched with a large number of new medicinal plants.[1] (A materia medica is a catalogue of medicinal substances.) For English herbals of the 1500s and 1600s, see Culpeper, Gerard and the English herbals.

From herbs to isolated compounds

The review says that in the early 19th century the discovery and isolation of alkaloids, from poppy (1806) and later from other plants, and then the isolation of glycosides, marked the beginning of scientific pharmacy.[1] From that point, some plant medicines could be studied as single purified compounds rather than whole herbs. For how today's rules treat herbs, see herbs and the law, and for plant-derived medicines see pharmacognosy and plant-derived medicines.

What history means for you

  • A long record of use can be a lead for research, but it is traditional use only until people are studied.
  • Some traditionally used plants have documented harms. For example, in 2001 the US FDA advised firms to remove comfrey supplements from the market,[4] and the US National Cancer Institute advises against herbal products that contain aristolochic acids.[5] Safety questions are answered in herb safety and interactions.
  • Ask a pharmacist or clinician before using any herb if you take medicines, are pregnant or breastfeeding, have liver or kidney disease, or have surgery planned.

Frequently asked questions

What is the oldest written record of herbal medicine?

The sources we read date a Chinese text to circa 2500 BC and the Ebers Papyrus to circa 1550 BC, both as given in one review.[1] Other records may exist that we did not read.

Who was Dioscorides?

A physician who, according to the review, wrote "De Materia Medica" circa 77 AD and noted forgery of drugs.[1]

Did old herbals get things wrong?

Yes. The review calls one of Dioscorides' camomile beliefs untrue.[1]

When did herbal medicine become modern pharmacy?

The review places the beginning of scientific pharmacy in the early 19th century, with the isolation of alkaloids and glycosides.[1]

Does a long history mean a herb is safe?

No. Proper evidence not found that age alone shows safety; we searched the historical review and NCCIH fact sheets. Safety comes from studies and regulator reviews. See traditional use vs research evidence.

References
  1. Petrovska BB. Historical review of medicinal plants' usage. Pharmacogn Rev 2012. Petrovska BB. Historical review of medicinal plants' usage. Pharmacogn Rev 2012. Read 2026-10-23.
  2. NCCIH, Echinacea (US). NCCIH, Echinacea (US). Read 2026-10-23.
  3. NCCIH, Licorice Root (US). NCCIH, Licorice Root (US). Read 2026-10-23.
  4. FDA, letter advising supplement manufacturers to remove comfrey products from the market, 6 July 2001 (US; archived copy). FDA, letter advising supplement manufacturers to remove comfrey products from the market, 6 July 2001 (US; archived copy). Read 2026-10-23.
  5. National Cancer Institute, Aristolochic Acids (US). National Cancer Institute, Aristolochic Acids (US). Read 2026-10-23.
Education, not medical advice. This page is for general information. It does not diagnose or treat any condition and is not a substitute for care from a qualified health professional. Natural does not automatically mean safe. Ask a clinician or pharmacist before changing your care, especially if you take medication, are pregnant or breastfeeding, or have a health condition.