Holistic Remedies · Ingredient
6-shogaol
Formula: C17H24O3 · MW: 276.376 · Drug-likeness: 0.547
⚗️ Identity
Name
6-shogaol
Aliases / Synonyms
Shogaol; 555-66-8; [6]-Shogaol; enexasogaol; (6)-Shogaol; 23513-13-5; (E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one; Trans-6-Shogaol; 1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one
🧪 Chemistry
Molecular Weight
276.3760
LogP
4.0390
Drug-likeness
0.547
Oral Bioavailability
31.0040
H-Bond Acceptors
3
H-Bond Donors
1
Rotatable Bonds
9
🔗 External References
0
Clinical Trials
2
Meta-Analyses
11
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
CRD42022334940
Anticancer effects of gingerol, shogaol and curcumin in cervical cancer: A systemic review.
CRD42023373613
Therapeutic Effects and Mechanisms of Action of Ginger and its Bioactive Components on Inflammatory Response, Oxidative Stress, Immune System and Organ Failure in Sepsis
📚 Sample References
PMID 24215632
6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α
Mol Cancer · 2013
PMID 23612072
6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ)
Cancer Lett · 2013
PMID 31675438
6-Shogaol, an active ingredient of ginger, inhibits osteoclastogenesis and alveolar bone resorption in ligature-induced periodontitis in mice
J Periodontol · 2020
PMID 31800263
Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model
Am J Physiol Lung Cell Mol Physiol · 2020
PMID 31938471
The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cells
Cell Biosci · 2020
PMID 33416981
6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway
Eur J Nutr · 2021