Holistic Remedies · Ingredient
Apigenin
Formula: C15H10O5 · MW: 270.24 · Drug-likeness: 0.632
⚗️ Identity
Name
Apigenin
Aliases / Synonyms
520-36-5; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; Versulin; Apigenol; Chamomile; 4',5,7-Trihydroxyflavone; Spigenin; Apigenine; C.I. Natural Yellow 1
🧪 Chemistry
Molecular Weight
270.2400
LogP
2.5768
Drug-likeness
0.632
Oral Bioavailability
23.0620
H-Bond Acceptors
5
H-Bond Donors
3
Rotatable Bonds
1
🔗 External References
HERB DB
PubChem CID
CAS Number
DrugBank
InChIKey
KZNIFHPLKGYRTM-UHFFFAOYSA-N
1
Clinical Trials
1
Meta-Analyses
53
PubMed References
Top Conditions Studied with Apigenin
📋 Sample Trials
NCT03526081
Absorption, Metabolism and Excretion of Apigenin and Apigenin Glycosides
Completed · Healthy
📊 Sample Meta-Analyses
CRD42020171272
Effect of apigenin for type 2 diabetes mellitus (T2DM): a preclinical systematic review and meta-analysis
📚 Sample References
PMID 27374313
Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization
EBioMedicine · 2016
PMID 28143892
Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension
Clin Sci (Lond) · 2017
PMID 29179721
Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
J Exp Clin Cancer Res · 2017
PMID 28056971
Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin
J Biomed Sci · 2017
PMID 31877350
Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity
Pharmacol Res · 2020
PMID 21871133
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90
Mol Cancer · 2011