Holistic Remedies · Ingredient
Baicalein
Formula: C15H10O5 · MW: 270.24 · Drug-likeness: 0.591
⚗️ Identity
Name
Baicalein
Aliases / Synonyms
491-67-8; 5,6,7-Trihydroxyflavone; Noroxylin; 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one; Biacalein; BaiKalein; 5,6,7-trihydroxy-2-phenylchromen-4-one; MFCD00017459; NSC 661431
🧪 Chemistry
Molecular Weight
270.2400
LogP
2.5768
Drug-likeness
0.591
Oral Bioavailability
33.5190
H-Bond Acceptors
5
H-Bond Donors
3
Rotatable Bonds
1
🔗 External References
0
Clinical Trials
0
Meta-Analyses
27
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 31000696
Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2
Cell Death Dis · 2019
PMID 28859441
Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response
J Antimicrob Chemother · 2017
PMID 25948105
Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPKα and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells
J Exp Clin Cancer Res · 2015
PMID 31746368
Baicalein inhibits the growth of oral squamous cell carcinoma cells by downregulating the expression of transcription factor Sp1
Int J Oncol · 2020
PMID 31909773
Baicalein reduces hepatic fat accumulation by activating AMPK in oleic acid-induced HepG2 cells and high-fat diet-induced non-insulin-resistant mice
Food Funct · 2020
PMID 32526964
Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System
Antioxidants (Basel) · 2020