Holistic Remedies · Ingredient
Calebin-a
Formula: C21H20O7 · MW: 384.3840000000001 · Drug-likeness: 0.533
⚗️ Identity
Name
Calebin-a
Aliases / Synonyms
Calebin A; 336784-82-8; U2M09W0E67; [(E)-4-(4-hydroxy-3-methoxyphenyl)-2-oxobut-3-enyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate; 2-propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (3E)-4-(4-hydroxy-3-methoxyphenyl)-2-oxo-3-butenyl ester, (2E)-; (E)-(E)-4-(4-Hydroxy-3-methoxyphenyl)-2-oxobut-3-en-1-yl 3-(4-hydroxy-3-methoxyphenyl)acrylate; 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (3E)-4-(4-hydroxy-3-methoxyphenyl)-2-oxo-3-buten-1-yl ester, (2E)-; CHEMBL86075;...
🧪 Chemistry
Molecular Weight
384.3840
LogP
2.9539
Drug-likeness
0.533
Oral Bioavailability
4.3290
H-Bond Acceptors
7
H-Bond Donors
2
Rotatable Bonds
8
🔗 External References
0
Clinical Trials
0
Meta-Analyses
4
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 32244288
Calebin A Potentiates the Effect of 5-FU and TNF-β (Lymphotoxin α) against Human Colorectal Cancer Cells: Potential Role of NF-κB
Int J Mol Sci · 2020
PMID 34276382
Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells
Front Pharmacol · 2021
PMID 34660256
Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment
Front Oncol · 2021
PMID 35163616
Calebin A, a Compound of Turmeric, Down-Regulates Inflammation in Tenocytes by NF-κB/Scleraxis Signaling
Int J Mol Sci · 2022