Holistic Remedies · Ingredient
Capsaicin
Formula: C18H27NO3 · MW: 305.4180000000001 · Drug-likeness: 0.539
⚗️ Identity
Name
Capsaicin
Aliases / Synonyms
404-86-4; (E)-Capsaicin; Zostrix; CAPSAICINE; Qutenza; Styptysat; Axsain; trans-Capsaicin; Isodecenoic acid vanillylamide
🧪 Chemistry
Molecular Weight
305.4180
LogP
3.7896
Drug-likeness
0.539
Oral Bioavailability
10.3100
H-Bond Acceptors
3
H-Bond Donors
2
Rotatable Bonds
9
🔗 External References
68
Clinical Trials
26
Meta-Analyses
35
PubMed References
Top Conditions Studied with Capsaicin
Pain 7
Healthy 7
Chest Pain 2
Osteoarthritis, Knee 2
Non-allergic Rhinitis 2
The clinical importance of utilising capsaicin as a prospect 1
Post Surgical Neuropathic Pain 1
Knee osteoarthritis（KOA）is a common chronic degenerative dis 1
Neuropathic Pain|Chronic Pain 1
Acute Pain 1
Cannabinoid hyperemesis syndrome (CHS) is a condition that i 1
Head and Neck Cancer|Radiation Toxicity 1
📋 Sample Trials
NCT00003610
Capsaicin Lozenges in Treating Patients With Mucositis Caused by Radiation Therapy
Completed · Phase 3 · Head and Neck Cancer|Radiation Toxicity
NCT00004316
Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis
Completed · Phase 1|Phase 2 · Interstitial Cystitis|Vulvar Diseases
NCT00008476
Capsaicin to Control Pain Following Third Molar Extraction
Completed · Phase 2 · Facial Pain
NCT00088686
Capsaicin to Control Pain Following Third Molar Extraction
Completed · Phase 2 · Healthy|Tooth Extraction
NCT00176969
Response of Topical Capsaicin in Alopecia Areata
Completed · Phase 4 · Alopecia Areata
NCT00471055
Efficacy Study on Symptomatic Control of Patient With Knee Osteoarthritis Between 0.0125% of Capsaicin to Placebo
Completed · Phase 3 · Osteoarthritis, Knee Joint|Capsicum
📊 Sample Meta-Analyses
CRD42016035254
Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: an individual patient data meta-analysis
Osteoarthritis is the most common joint disorder, and frequently affects the kne
CRD42018079825
Capsaicin as an ergogenic aid: a systematic review
Our group recently demonstrated that acute capsaicin supplementation (12 mg) inc
CRD42020181639
The effectiveness, efficacy and adverse events of topical capsaicin to treat cutaneous itch: a systematic review and meta-analysis
Topical capsaicin to treat patients with cutaneous itch conditions or itch-assoc
CRD42020213306
Efficacy of pain management in adult patients with diabetic peripheral neuropathy treated with capsaicin versus gabapentin
Diabetic peripheral neuropathy involves neurovascular impairment with poor repai
CRD42021227824
Efficacy of Capsaicin for Cannabinoid hyperemesis syndrome in the Emergency Department, A systematic Review and Meta-analysis
Cannabinoid hyperemesis syndrome (CHS) is a condition that is being recognized a
CRD42021228032
The Effects of Capsaicin Supplementation on Blood Lipid levels and Inflammatory Markers among Patients with Metabolic Syndrome or Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Dyslipidemia is an important risk factor for many chronic diseases. LDL-C, HDL-C
📚 Sample References
PMID 31635402
Capsaicin Targets tNOX (ENOX2) to Inhibit G1 Cyclin/CDK Complex, as Assessed by the Cellular Thermal Shift Assay (CETSA)
Cells · 2019
PMID 31782192
Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway
Phytother Res · 2020
PMID 32375895
Immunomodulatory and anti-oxidative effect of the direct TRPV1 receptor agonist capsaicin on Schwann cells
J Neuroinflammation · 2020
PMID 32685028
Therapeutic potential of targeting MKK3-p38 axis with Capsaicin for Nasopharyngeal Carcinoma
Theranostics · 2020
PMID 32982728
Capsaicin Is a Negative Allosteric Modulator of the 5-HT3 Receptor
Front Pharmacol · 2020
PMID 33016967
Eugenol and capsaicin exhibit anti-metastatic activity via modulating TGF-β signaling in gastric carcinoma
Food Funct · 2020
🏥 Linked Health Topics 11 · matched via study conditions