natural remedies · Ingredient
Citrulline
Formula: C6H13N3O3 · MW: 175.188 · Drug-likeness: 0.394
⚗️ Identity
Name
Citrulline
Aliases / Synonyms
L-citrulline; 372-75-8; H-cit-oh; delta-Ureidonorvaline; Sitrulline; (S)-2-Amino-5-ureidopentanoic acid; N5-Carbamoyl-L-ornithine; L-Cytrulline; Citrulline, L-
🧪 Chemistry
Molecular Weight
175.1880
LogP
-1.1532
Drug-likeness
0.394
H-Bond Acceptors
3
H-Bond Donors
4
Rotatable Bonds
5
🔗 External References
18
Clinical Trials
6
Meta-Analyses
2
PubMed References
Top Conditions Studied with Citrulline
Mitochondrial Diseases 1
Cardiovascular Diseases|Heart Diseases|Heart Defects, Congen 1
The domain being studied is within the field of exercise per 1
Metabolism|Elderly 1
Atorvastatin 1
Recovering after a physical fitness 1
Menopause 1
Physical exercise, both aerobic and anaerobic 1
MELAS Syndrome 1
It has been suggested that citrulline (CIT; a non-proteinoge 1
Intestinal Failure 1
Fatigue during physical performance and potential nitric oxi 1
📋 Sample Trials
NCT00201214
Citrulline for Children Undergoing Cardiopulmonary Bypass Surgery
Completed · Phase 1|Phase 2 · Cardiovascular Diseases|Heart Diseases|H
NCT00714675
Citrulline and Protein Metabolism in the Malnourished Elderly People
Completed · Metabolism|Elderly
NCT01599676
Citrulline, Exercise Training and Muscle Strength in the Elderly
Completed · Elderly Patients
NCT01849107
Plasma Citrulline: A Marker for Monitoring & Quantifying Radiation-Induced Small Bowel Toxicity
Completed · Diarrhea|Anorexia|Dyspepsia
NCT02417428
Citrulline Supplementation Combined With Exercise: Effect on Muscle Function in Elderly People (CITEX Study)
Completed · Sarcopenia|Obesity
NCT02801695
Evaluation of the Efficacy of Citrulline Supplementation on the Delay of Delivery for Women Hospitalized for Pre-eclampsia (CITRUPE)
Completed · Phase 2|Phase 3 · Pre-eclampsia|Pregnancy
📊 Sample Meta-Analyses
CRD42019115488
The effect of L-citrulline on the subjective feeling of fatigue and exercise performance
Physical exercise, both aerobic and anaerobic
CRD42019145681
Effects of citrulline alone or combined with exercise on muscle mass, muscle strength and physical performance among older adults: a systematic review (Protocol)
It has been suggested that citrulline (CIT; a non-proteinogenic amino acid) supp
CRD42020159338
Effects of citrulline supplementation on resistance training responses: a systematic review and meta-analysis of randomized controlled trials
The effects of citrulline supplementation on muscle soreness, strength and endur
CRD42020179291
The effect of Citrulline supplementation on exercise performance in healthy adults
The domain being studied is within the field of exercise performance. This inclu
CRD42021287530
The effect of L-arginine, L-citrulline and combined L-arginine with L-citrulline oral supplementation on athletic or physical performance: systematic review
Fatigue during physical performance and potential nitric oxide production dysfun
CRD42022359806
Influence of arginine and citrulline on biomarkers of inflammation and oxidative stress in response to physical exercise and recovery: A systematic review with meta-analysis.
Recovering after a physical fitness
📚 Sample References
PMID 35460170
Citrulline protects human retinal pigment epithelium from hydrogen peroxide and iron/ascorbate induced damages
J Cell Mol Med · 2022
PMID 36564641
Citrulline enteral administration markedly reduces immunosuppressive extrafollicular plasma cell differentiation in a preclinical model of sepsis
Eur J Immunol · 2022
🏥 Linked Health Topics 2 · matched via study conditions