Holistic Remedies · Ingredient
Cocaine
Formula: C17H21NO4 · MW: 303.3580000000001 · Drug-likeness: 0.798
⚗️ Identity
Name
Cocaine
Aliases / Synonyms
Benzoylmethylecgonine; Neurocaine; Kokain; L-Cocaine; Cocain; Cocaina; beta-Cocain; (-)-Cocaine; cocainum
🧪 Chemistry
Molecular Weight
303.3580
LogP
1.8677
Drug-likeness
0.798
H-Bond Acceptors
5
Rotatable Bonds
3
🔗 External References
29
Clinical Trials
26
Meta-Analyses
19
PubMed References
Top Conditions Studied with Cocaine
Cocaine Use Disorder 8
Cocaine Dependence 6
Cocaine-Related Disorders 3
The consumption of psychoactive substances has been consider 2
Hyperthermia|Cocaine Use|Exercise 1
Any Ear Nose or Throat Conditions|With Identified Need for a 1
Crack cocaine is a drug of abuse that stimulates the central 1
Epistaxis 1
The condition being studied is substance use disorders (SUD) 1
Active Cocaine Users 1
Cocaine’s intense stimulant effect and addictive properties 1
Cocaine-Related Disorders|Substance Withdrawal Syndrome|Subs 1
📋 Sample Trials
NCT00451230
Metabolic Effects of Cocaine
Completed · Cocaine Dependence
NCT01851473
Interactions Between Intravenous Cocaine and Acetazolamide or Quinine
Completed · Phase 1 · Cocaine Use|Pharmacokinetics
NCT01906346
Impact of a Non-Drug Choice on Cocaine Reinforcement
Completed · Early_Phase 1 · Cocaine Dependence
NCT02141620
n-Acetylcysteine and Cocaine
Completed · Early_Phase 1 · Cocaine Abuse|Cocaine Dependence
NCT02233647
Phendimetrazine and Cocaine
Completed · Early_Phase 1 · Cocaine Use Disorder
NCT02239913
Topiramate-Phentermine Combinations for Cocaine Dependence
Completed · Phase 1 · Cocaine Use Disorder
📊 Sample Meta-Analyses
CRD42023393427
Behavioral techniques in effective harm reduction interventions with cocaine users: a systematic review
Harm reduction interventions using behavior modification techniques
CRD42022378254
Acute Cocaine Use and Outcomes After Ischemic or Hemorrhage Stroke: A Systematic Review of Clinical Evidence
Ischemic and Hemorrhagic Stroke
CRD42016035486
Crack-cocaine use and health consequences: systematic review and meta-analysis
CRD42017052277
Maternal, fetal and neonatal consequences associated with crack cocaine use during gestational period: a systematic review
Crack cocaine is a drug of abuse that stimulates the central nervous system. In
CRD42018094623
Systematic review of mortality among people with regular or problematic use of opioids, cocaine, or amphetamine
The purpose of this review is to present an updated global review of the availab
CRD42019124464
Cocaine addiction in mental disorders: a self-medication hypothesis systematic review protocol
Lifetime prevalence of drug use and dependence disorder (SUD) in US has been est
📚 Sample References
PMID 31557508
Chemokine CCR5 and cocaine interactions in the brain: Cocaine enhances mesolimbic CCR5 mRNA levels and produces place preference and locomotor activation that are reduced by a CCR5 antagonist
Brain Behav Immun · 2020
PMID 29859319
Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production
Neurobiol Dis · 2018
PMID 31266052
Sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone
Neuropsychopharmacology · 2020
PMID 31805281
Administration of a novel high affinity PICK1 PDZ domain inhibitor attenuates cocaine seeking in rats
Neuropharmacology · 2020
PMID 31998080
Cocaine Self-administration and Extinction Inversely Alter Neuron to Glia Exosomal Dynamics in the Nucleus Accumbens
Front Cell Neurosci · 2020
PMID 32978730
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration
Mol Neurobiol · 2021
🏥 Linked Health Topics 5 · matched via study conditions