Holistic Remedies · Ingredient
Costunolide
Formula: C15H20O2 · MW: 232.3229999999999 · Drug-likeness: 0.363
⚗️ Identity
Name
Costunolide
Aliases / Synonyms
553-21-9; (+)-costunolide; Costunlide; Costunolid; Costus lactone; CHEMBL86416; CHEBI:3900; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one
🧪 Chemistry
Molecular Weight
232.3230
LogP
3.5508
Drug-likeness
0.363
Oral Bioavailability
29.0700
H-Bond Acceptors
2
🔗 External References
0
Clinical Trials
0
Meta-Analyses
13
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 31621893
Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation
Br J Pharmacol · 2019
PMID 29037867
Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer
Cancer Lett · 2018
PMID 28914393
Costunolide induces micronuclei formation, chromosomal aberrations, cytostasis, and mitochondrial-mediated apoptosis in Chinese hamster ovary cells
Cell Biol Toxicol · 2018
PMID 27148686
Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma
Cell Death Dis · 2016
PMID 21421237
Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer
J Urol · 2011
PMID 33194716
Costunolide Induces Autophagy and Apoptosis by Activating ROS/MAPK Signaling Pathways in Renal Cell Carcinoma
Front Oncol · 2020