natural remedies · Ingredient
Diosmetin
Formula: C16H12O6 · MW: 300.266 · Drug-likeness: 0.672
⚗️ Identity
Name
Diosmetin
Aliases / Synonyms
520-34-3; 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one; Luteolin 4'-methyl ether; 4'-Methylluteolin; Salinigricoflavonol; Diosmetine; Pillon; 3',5,7-trihydroxy-4'-methoxyflavone; 5,7,3'-Trihydroxy-4'-methoxyflavone
🧪 Chemistry
Molecular Weight
300.2660
LogP
2.5854
Drug-likeness
0.672
Oral Bioavailability
31.1380
H-Bond Acceptors
6
H-Bond Donors
3
Rotatable Bonds
2
🔗 External References
0
Clinical Trials
0
Meta-Analyses
11
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 30825187
Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells via Nrf2 inhibition
Br J Pharmacol · 2019
PMID 31833613
Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-κB signaling pathways
Phytother Res · 2020
PMID 33449987
Diosmetin attenuates metabolic syndrome and left ventricular alterations via the suppression of angiotensin II/AT 1 receptor/gp91 phox/p-NF-κB protein expression in high-fat diet fed rats
Food Funct · 2021
PMID 34091150
Diosmetin ameliorate type 2 diabetic mellitus by up-regulating Corynebacterium glutamicum to regulate IRS/PI3K/AKT-mediated glucose metabolism disorder in KK-Ay mice
Phytomedicine · 2021
PMID 34262136
Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis
Acta Pharmacol Sin · 2022
PMID 34573119
Diosmetin Ameliorates Vascular Dysfunction and Remodeling by Modulation of Nrf2/HO-1 and p-JNK/p-NF-κB Expression in Hypertensive Rats
Antioxidants (Basel) · 2021
🔗 Knowledge Graph Connections
Open full graph →Real research connections from HERB 2.0, TCMSP, and clinical evidence sources. 23 related entities shown — click any to follow the trail.
🌿 Herbs containing this compound · 1
🧬 Gene targets · 10
Prostaglandin G/H synthase 2
binding 0.861
Trypsin-1
binding 0.847
Heat shock protein HSP 90
binding 0.843
mRNA of PKA Catalytic Subunit C-alpha
binding 0.832
NCOA2
NCOA2
binding 0.819
Nitric oxide synthase, inducible
binding 0.815
Dipeptidyl peptidase IV
binding 0.782
Calmodulin
binding 0.781
NCOA1
NCOA1
binding 0.774
Prostaglandin G/H synthase 1
binding 0.761
🏥 Linked health topics · 12
Abdominal aortic aneurysm
disease
Adenomatous polyposis
disease
Alzheimer'S Disease
syndrome
Analgesics
disease
Arthritis
syndrome
Autoimmune Diseases
group
Bladder cancer
disease
Breast cancer
disease
Cancer, unspecific
disease
Carcinoma in situ, unspecified
disease
Cardiovascular disease, unspecified
disease
Carpal Tunnel Syndrome
syndrome