Holistic Remedies · Ingredient
Fraxetin
Formula: C10H8O5 · MW: 208.169 · Drug-likeness: 0.544
⚗️ Identity
Name
Fraxetin
Aliases / Synonyms
574-84-5; 7,8-Dihydroxy-6-methoxy-2H-chromen-2-one; 7,8-Dihydroxy-6-methoxycoumarin; 7,8-dihydroxy-6-methoxychromen-2-one; 2H-1-Benzopyran-2-one, 7,8-dihydroxy-6-methoxy-; 7,8-Dihydroxy-6-methoxy-chromen-2-one; 7,8-Dihydroxy-6-methoxy-2-benzopyrone; CD3GD44O3K; CHEMBL54909
🧪 Chemistry
Molecular Weight
208.1690
LogP
1.2128
Drug-likeness
0.544
Oral Bioavailability
23.0410
H-Bond Acceptors
5
H-Bond Donors
2
Rotatable Bonds
1
🔗 External References
0
Clinical Trials
0
Meta-Analyses
6
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 32504672
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway
Int J Biochem Cell Biol · 2020
PMID 33477262
Fraxetin Suppresses Cell Proliferation and Induces Apoptosis through Mitochondria Dysfunction in Human Hepatocellular Carcinoma Cell Lines Huh7 and Hep3B
Pharmaceutics · 2021
PMID 34523750
Fraxetin exerts anticancer effect in glioma by suppressing MiR-21-3p
Drug Dev Res · 2021
PMID 35387563
Fraxetin down-regulates polo-like kinase 4 (PLK4) to inhibit proliferation, migration and invasion of prostate cancer cells through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway
Bioengineered · 2022
PMID 36290616
Suppressive Effect of Fraxetin on Adipogenesis and Reactive Oxygen Species Production in 3T3-L1 Cells by Regulating MAPK Signaling Pathways
Antioxidants (Basel) · 2022
PMID 36377917
Inhibition of the Type III Secretion System of Salmonella enterica Serovar Typhimurium via Treatment with Fraxetin
Microbiol Spectr · 2022