Holistic Remedies · Ingredient
Genistein
Formula: C15H10O5 · MW: 270.24 · Drug-likeness: 0.632
⚗️ Identity
Name
Genistein
Aliases / Synonyms
446-72-0; Prunetol; 4',5,7-Trihydroxyisoflavone; Genisterin; Genisteol; Sophoricol; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7,4'-Trihydroxyisoflavone; Bonistein
🧪 Chemistry
Molecular Weight
270.2400
LogP
2.5768
Drug-likeness
0.632
Oral Bioavailability
17.9330
H-Bond Acceptors
5
H-Bond Donors
3
Rotatable Bonds
1
🔗 External References
22
Clinical Trials
11
Meta-Analyses
29
PubMed References
Top Conditions Studied with Genistein
Metabolic Syndrome 2
Menopause|Osteopenia 2
Cancer 2
Breast Cancer 2
Metabolic Syndrome|Obesity 1
Bladder Cancer 1
in this review the effect of genistein supplementation on bo 1
Alzheimer's Disease 1
Hot flash (hot flush) in postmenopausal women. 1
Central features of metabolic syndrome (MetS). 1
Kidney Cancer|Melanoma (Skin) 1
Bone density loss in postmenopausal women. 1
📋 Sample Trials
NCT00001696
A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor
Completed · Phase 1 · Cancer
NCT00016744
Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis)
Completed · Phase 1|Phase 2 · Cystic Fibrosis
NCT00099008
Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women
Completed · Phase 1 · Breast Cancer|Endometrial Cancer
NCT00118040
Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer
Completed · Phase 2 · Recurrent Bladder Carcinoma|Stage I Blad
NCT00244933
Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer
Completed · Phase 2 · Breast Cancer
NCT00276835
Genistein and Interleukin-2 in Treating Patients With Metastatic Melanoma or Kidney Cancer
Completed · Early_Phase 1 · Kidney Cancer|Melanoma (Skin)
📊 Sample Meta-Analyses
CRD42017069513
Systematic review and meta-analysis of effect of genistein on endometrial thickness in postmenopausal women
Postmenopausal estrogen decline increases incidence of vasomotor symptoms, cardi
CRD42017069604
Effect of genistein on bone mineral density in postmenopausal women: a systematic review and meta-analysis
Bone density loss in postmenopausal women.
CRD42017069617
Effect of genistein on hot flash in postmenopausal women :a systematic review and meta-analysis
Hot flash (hot flush) in postmenopausal women.
CRD42022310933
Safety and Efficacy of Genistein in Sanfilippo Syndrome - A Systematic Review
Sanfilippo Syndrome (MPS III)
CRD42022322440
Therapeutic effects and mechanisms of action of genistein on in Non-alcoholic fatty liver: A systematic review
Non-alcoholic fatty liver disease (NAFLD), one of the most prevalent health prob
CRD42022325833
The effect of genistein supplementation on glycemic control and insulin sensitivity: A systematic review and meta-analysis of randomized controlled trials
In this study, we will review the effect of genistein on glycemic control and in
📚 Sample References
PMID 31747621
Fetal and neonatal genistein exposure aggravates to interfere with ovarian follicle development of obese female mice induced by high-fat diet
Food Chem Toxicol · 2020
PMID 31795012
Genistein protects against amyloid-beta-induced toxicity in SH-SY5Y cells by regulation of Akt and Tau phosphorylation
Phytother Res · 2020
PMID 32078221
Anti-invasive effect and pharmacological mechanism of genistein against colorectal cancer
Biofactors · 2020
PMID 32115816
Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation
Phytother Res · 2020
PMID 32129363
Genistein inhibits high fat diet-induced obesity through miR-222 by targeting BTG2 and adipor1
Food Funct · 2020
PMID 32278794
Role of the TLR4-androgen receptor axis and genistein in taxol-resistant ovarian cancer cells
Biochem Pharmacol · 2020
🏥 Linked Health Topics 8 · matched via study conditions