Holistic Remedies · Ingredient
Harmine
Formula: C13H12N2O · MW: 212.252 · Drug-likeness: 0.673
⚗️ Identity
Name
Harmine
Aliases / Synonyms
442-51-3; 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole; Banisterine; Telepathine; Leucoharmine; Yageine; Yajeine; 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-; 7-Methoxy-1-methyl-9H-beta-carboline
🧪 Chemistry
Molecular Weight
212.2520
LogP
3.0331
Drug-likeness
0.673
H-Bond Acceptors
2
H-Bond Donors
1
Rotatable Bonds
1
🔗 External References
HERB DB
PubChem CID
CAS Number
DrugBank
InChIKey
BXNJHAXVSOCGBA-UHFFFAOYSA-N
3
Clinical Trials
0
Meta-Analyses
9
PubMed References
Top Conditions Studied with Harmine
📋 Sample Trials
NCT04716335
Neurodynamics of Prosocial Emotional Processing Following Serotonergic Stimulation With N,N-Dimethyltryptamine (DMT) and Harmine in Healthy Subjects
Completed · Early_Phase 1 · Emotions|Mood|Cognitive Function 1, Soci
NCT05526430
Study of Harmine in Healthy Subjects
Completed · Phase 1 · Diabetes Mellitus
NCT05829603
Dose-finding Study for the Combination of DMT and Harmine in Healthy Subjects
Completed · Phase 1 · Healthy
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 32032735
The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo
Neurobiol Dis · 2020
PMID 32425784
Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats
Front Pharmacol · 2020
PMID 33474722
Harmine alleviates atherogenesis by inhibiting disturbed flow-mediated endothelial activation via protein tyrosine phosphatase PTPN14 and YAP
Br J Pharmacol · 2021
PMID 33508300
Harmine inhibits the proliferation and migration of glioblastoma cells via the FAK/AKT pathway
Life Sci · 2021
PMID 33785860
Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy
Acta Pharmacol Sin · 2022
PMID 33960660
Harmine targets inhibitor of DNA binding-2 and activator protein-1 to promote preosteoclast PDGF-BB production
J Cell Mol Med · 2021
🏥 Linked Health Topics 1 · matched via study conditions