natural remedies · Ingredient
Hypericin
Formula: C30H16O8 · MW: 504.4500000000003 · Drug-likeness: 0.123
⚗️ Identity
Name
Hypericin
Aliases / Synonyms
548-04-9; Hypericum red; Cyclosan; hipericin; hipericina; hypericine; Mycoporphyrin; Hyperizin; Cyclo-Werol
🧪 Chemistry
Molecular Weight
504.4500
LogP
5.0810
Drug-likeness
0.123
Oral Bioavailability
14.6650
H-Bond Acceptors
8
H-Bond Donors
6
🔗 External References
6
Clinical Trials
1
Meta-Analyses
3
PubMed References
Top Conditions Studied with Hypericin
📋 Sample Trials
NCT00000645
A Phase I Dose Escalation Study of Synthetic Hypericin in HIV-Infected Patients With Less Than 300 CD4 Lymphocytes
Completed · Phase 1 · HIV Infections
NCT00000792
A Pharmacologically Guided Phase I/II Study of Daily Orally Administered Synthetic Hypericin in HIV-Infected Subjects
Completed · Phase 1 · HIV Infections
NCT02448381
FLASH [Fluorescent Light Activated Synthetic Hypericin] Clinical Study: Topical SGX301 (Synthetic Hypericin) for the Treatment of Cutaneous T-Cell Lymphoma (Mycosis Fungoides)
Completed · Phase 3 · Cutaneous T-Cell Lymphoma
NCT05442190
Topical SGX302 for Mild-to-Moderate Psoriasis
Recruiting · Phase 2 · Psoriasis|Plaque Psoriasis|Psoriasis Vul
NCT05872854
Treatment of Mycosis Fungoides With Hypericin Ointment and Visible Light
Recruiting · Phase 2 · Cutaneous T Cell Lymphoma|Mycosis Fungoi
NCT06149247
HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment of CTCL
Completed · Phase 2 · Cutaneous T-Cell Lymphoma/Mycosis Fungoi
📊 Sample Meta-Analyses
CRD42022363626
Antimicrobial effects of hypericin and pseudohypericin: a systematic review.
📚 Sample References
PMID 34710555
Anti-fatigue effect of hypericin in a chronic forced exercise mouse model
J Ethnopharmacol · 2021
PMID 35101848
The protective effect of hypericin on postpartum depression rat model by inhibiting the NLRP3 inflammasome activation and regulating glucocorticoid metabolism
Int Immunopharmacol · 2022
PMID 35811028
Hypericin blocks the function of HSV-1 alkaline nuclease and suppresses viral replication
J Ethnopharmacol · 2022
🏥 Linked Health Topics 2 · matched via study conditions