natural remedies · Ingredient
L-ascorbic acid
Formula: C6H8O6 · MW: 176.124 · Drug-likeness: 0.385
⚗️ Identity
Name
L-ascorbic acid
Aliases / Synonyms
ascorbic acid; vitamin C; 50-81-7; L-ascorbate; Ascoltin; ascorbate; Ascorbicap; Cevitamic acid; L(+)-Ascorbic acid
🧪 Chemistry
Molecular Weight
176.1240
LogP
-1.4074
Drug-likeness
0.385
H-Bond Acceptors
6
H-Bond Donors
4
Rotatable Bonds
2
🔗 External References
178
Clinical Trials
17
Meta-Analyses
46
PubMed References
Top Conditions Studied with L-ascorbic acid
📋 Sample Trials
NCT00231218
Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers
Completed · Phase 3 · Common Cold|Gastroenteritis
NCT03258684
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock
Completed · Sepsis
NCT03333278
The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial
Completed · Phase 2 · Shock, Septic|Critically Ill|Vasoplegic
NCT03592693
Vitamin C, Hydrocortisone and Thiamine for Septic Shock
Recruiting · Phase 2 · Shock, Septic
NCT03872011
Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock
Completed · Phase 3 · Septic Shock
NCT04160676
Therapy With Hydrocortisone, Ascorbic Acid, Thamine in Patients With Sepsis
Completed · Sepsis
📊 Sample Meta-Analyses
CRD42020203166
Hydrocortisone, ascorbic acid and thiamine for sepsis and septic shock: a meta-analysis
The effect of treatment with hydrocortisone, ascorbic acid, and thiamine for sep
CRD42020207832
Combined treatment with ascorbic acid, hydrocortisone, and thiamine for patients with sepsis and septic shock: a systematic review and meta-analysis
Sepsis rapidly progresses causing multiple organ dysfunction, and is considered
CRD42020220135
Thiamine, ascorbic acid and hydrocortisone as metabolic resuscitation cocktail in sepsis: where is the evidence ? A meta-analysis of randomised controlled trial with trial sequential analysis.
Septic shock, Sepsis, metabolic resuscitation
CRD42022296055
Comparisson of Hydrocortisone with Combined Hydrocortisone, Ascorbic Acid, and Thiamine as an Adjuvant Therapy on Septic Shock Patients on Mortality: A Systematic Review and Meta-analisis
The adjuvant therapy of septic shock is not yet defined, even with the new guild
CRD42020167426
Lower-volume Polyethylene Glycol with Ascorbic Acid plus Adjunctive Drugs Preparations are Not Inferior to Low-volume Bowel Cleansing Regimens: a Meta-analysis of Randomized, Controlled Trials
Colonoscopy.Bowel preparation
CRD42018093372
The effect of ascorbic acid on chronic kidney disease-mineral and bone disorder in hemodialysis patients: a systematic review and meta-analysis
Hemodialysis. Chronic kidney disease mineral bone metabolism disorder.
📚 Sample References
PMID 31476335
Ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effects
Prog Neuropsychopharmacol Biol Psychiatry · 2020
PMID 31656084
Ascorbic Acid 2-Glucoside Stably Promotes the Primitiveness of Embryonic and Mesenchymal Stem Cells Through Ten-Eleven Translocation- and cAMP-Responsive Element-Binding Protein-1-Dependent Mechanisms
Antioxid Redox Signal · 2020
PMID 31911474
High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model
Proc Natl Acad Sci U S A · 2020
PMID 31926565
Attenuation of sleep deprivation dependent deterioration in male fertility parameters by vitamin C
Reprod Biol Endocrinol · 2020
PMID 31936891
Supporting Cell-Based Tendon Therapy: Effect of PDGF-BB and Ascorbic Acid on Rabbit Achilles Tenocytes in Vitro
Int J Mol Sci · 2020
PMID 32013700
Vitamin C Intravenous Treatment In the Setting of Atrial Fibrillation Ablation: Results From the Randomized, Double-Blinded, Placebo-Controlled CITRIS-AF Pilot Study
J Am Heart Assoc · 2020
🏥 Linked Health Topics 12 · matched via study conditions