natural remedies · Ingredient
Melatonin
Formula: C13H16N2O2 · MW: 232.283 · Drug-likeness: 0.845
⚗️ Identity
Name
Melatonin
Aliases / Synonyms
73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; 5-Methoxy-N-acetyltryptamine; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine
🧪 Chemistry
Molecular Weight
232.2830
LogP
1.8551
Drug-likeness
0.845
Oral Bioavailability
52.9610
H-Bond Acceptors
2
H-Bond Donors
2
Rotatable Bonds
4
🔗 External References
215
Clinical Trials
205
Meta-Analyses
99
PubMed References
Top Conditions Studied with Melatonin
📋 Sample Trials
NCT00097474
Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag
Completed · Phase 2 · Jet Lag
NCT02639741
Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia
Completed · Phase 4 · Postoperative Pain
NCT04530539
The Effect of Melatonin and Vitamin C on COVID-19
Completed · Covid19|SARS-CoV Infection
NCT00000171
Study of Melatonin: Sleep Problems in Alzheimer's Disease
Completed · Phase 3 · Alzheimer Disease|Dyssomnias
NCT00230737
Effects of Melatonin on Insomnia Symptoms in Older Adults
Completed · Phase 2 · Sleep Initiation and Maintenance Disorde
NCT00238108
Melatonin Supplements for Improving Sleep in Individuals With Hypertension
Completed · Phase 2 · Sleep Disorders|Hypertension
📊 Sample Meta-Analyses
CRD42020207400
Use of melatonin in cisplatin-induced loss of primordial follicles in mice ovaries: systematic review
CRD42021276835
Can oral exogenous melatonin be a standard or adjunct treatment for patients with hypertension? A systematic review and meta-analysis
Hypertension
CRD42021236174
Exogenous melatonin for sleep disturbances in Parkinson`s disease: a systematic review with meta-analysis
Sleep disturbances in Parkinson`s disease
CRD42020221060
Effects of long-term melatonin treatment on fasting plasma glucose, insulin, HbA1c and HOMA – A systematic review
althy adults or adult patients with metabolic disease (Type 2 diabetes (T2DM), n
CRD42021283962
Melatonin and ramelteon in the treatment of delirium - A systematic review
Delirium, defined as a disturbance of attention, awareness and a change in basel
CRD42020201910
Melatonin levels in periodontal disease vs health: A systematic review and meta-analysis
periodontal disease which is an oral inflammatory condition of bacterial origin
📚 Sample References
PMID 31605630
Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy
J Pineal Res · 2020
PMID 31710386
Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation
J Pineal Res · 2020
PMID 31743484
Melatonin ameliorates SGLT2 inhibitor-induced diabetic ketoacidosis by inhibiting lipolysis and hepatic ketogenesis in type 2 diabetic mice
J Pineal Res · 2020
PMID 31762195
Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke
J Cell Mol Med · 2020
PMID 31863775
Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice
Life Sci · 2020
PMID 31867684
Melatonin modulates airway smooth muscle cell phenotype by targeting the STAT3/Akt/GSK-3β pathway in experimental asthma
Cell Tissue Res · 2020
🏥 Linked Health Topics 12 · matched via study conditions
Anxiety
disease
Aortic Aneurysm
syndrome
Burning Mouth Syndrome
syndrome
Carotid Stenosis
syndrome
Delirium
disease
Dyspepsia
phenotype
Epilepsy
syndrome
Fatigue
phenotype
Fetal Growth Retardation
phenotype
Genital Herpes
syndrome
Huntington Disease
syndrome
Sleep Initiation And Maintenance Disorders
syndrome