natural remedies · Ingredient
Menthol
Formula: C10H20O · MW: 156.269 · Drug-likeness: 0.618
⚗️ Identity
Name
Menthol
Aliases / Synonyms
dl-Menthol; 1490-04-6; 2-Isopropyl-5-methylcyclohexanol; 15356-70-4; 89-78-1; Cyclohexanol, 5-methyl-2-(1-methylethyl)-; Menthyl alcohol; p-Menthan-3-ol; Mentholum
🧪 Chemistry
Molecular Weight
156.2690
LogP
2.4395
Drug-likeness
0.618
H-Bond Acceptors
1
H-Bond Donors
1
Rotatable Bonds
1
🔗 External References
19
Clinical Trials
9
Meta-Analyses
6
PubMed References
Top Conditions Studied with Menthol
Hypertension|Prehypertension 1
Acute Exercise|Heat Exposure 1
Surgical patients with perioperative fasting 1
Electronic Cigarette Use|Cigarette Use, Electronic|Tobacco U 1
Actinic Keratosis 1
Hospitalized patients with symptoms of thirst received eithe 1
Electronic Cigarette Use 1
Gastrointestinal (GI) endoscopy is a commonly used diagnosti 1
Dyspnea|Chronic Obstructive Pulmonary Disease 1
Chronic breathlessness is a feeling of breathing discomfort 1
Diabetic Peripheral Neuropathy 1
Tobacco Use Disorder 1
📋 Sample Trials
NCT02984072
Menthol for PDT Pain Relief
Completed · Phase 4 · Actinic Keratosis
NCT02102100
The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
Completed · Nicotine Dependence
NCT03626519
Effects of Menthol on Dyspnoea in COPD Patients
Completed · Copd|Dyspnea|Lung Diseases
NCT03164668
Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes
Completed · Tobacco Use Disorder
NCT02728687
Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy
Completed · Phase 1|Phase 2 · Diabetic Peripheral Neuropathy
NCT01408446
Effects and Safety of Menthol on Blood Pressure and Metabolic Parameters in Prehypertensive and Mild Hypertensive Patients
Completed · Phase 2|Phase 3 · Hypertension|Prehypertension
📊 Sample Meta-Analyses
CRD42016036654
Menthol versus non-menthol cigarette use and smoking initiation, cessation, and dependence: a systematic review
The behaviours of smoking initiation and progression to regular smoking, smoking
CRD42019119301
Menthol versus non-menthol cigarette use and smoking initiation, cessation, and dependence: an updated systematic review
The behaviors of smoking initiation and progression to regular smoking, smoking
CRD42019125034
Thermophysiological and cardiovascular effects of menthol during physical exercise
Thermophysiological and cardiovascular effects of menthol application in healthy
CRD42020156087
The Impact of Menthol Cigarette Bans
The impact of menthol cigarette bans on tobacco use.
CRD42020166841
Impact of non-menthol flavors in tobacco products on perception and use among youth, young adults and adults: an updated systematic review and meta-analysis
tobacco control
CRD42020171050
Effects of menthol on breathing sensations: A systematic review
Chronic breathlessness is a feeling of breathing discomfort which persists despi
📚 Sample References
PMID 32728032
Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
Nat Commun · 2020
PMID 34834317
The Use of Menthol in Skin Wound Healing-Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization
Pharmaceutics · 2021
PMID 35334439
Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia
Neurobiol Aging · 2022
PMID 35682765
Effect of Skin Ion Channel TRPM8 Activation by Cold and Menthol on Thermoregulation and the Expression of Genes of Thermosensitive TRP Ion Channels in the Hypothalamus of Hypertensive Rats
Int J Mol Sci · 2022
PMID 35814769
The Severity of Acute Kidney and Lung Injuries Induced by Cecal Ligation and Puncture Is Attenuated by Menthol: Role of Proliferating Cell Nuclear Antigen and Apoptotic Markers
Front Med (Lausanne) · 2022
PMID 36120368
Protective effects of menthol against sepsis-induced hepatic injury: Role of mediators of hepatic inflammation, apoptosis, and regeneration
Front Pharmacol · 2022
🏥 Linked Health Topics 7 · matched via study conditions