Holistic Remedies · Ingredient
Nobiletin
Formula: C21H22O8 · MW: 402.3990000000002 · Drug-likeness: 0.594
⚗️ Identity
Name
Nobiletin
Aliases / Synonyms
478-01-3; Hexamethoxyflavone; 3',4',5,6,7,8-Hexamethoxyflavone; 5,6,7,8,3',4'-Hexamethoxyflavone; 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one; 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one; NSC-76751; CCRIS 9012; UNII-D65ILJ7WLY
🧪 Chemistry
Molecular Weight
402.3990
LogP
3.5116
Drug-likeness
0.594
Oral Bioavailability
61.6690
H-Bond Acceptors
8
Rotatable Bonds
7
🔗 External References
0
Clinical Trials
1
Meta-Analyses
17
PubMed References
Top Conditions Studied with Nobiletin
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
CRD42022273731
The antimicrobial activity of naringin and other flavanones against pathogenic oral bacteria: A systematic review
Flavonoids are natural compounds that have been proved to be beneficial for huma
📚 Sample References
PMID 31964763
The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK
J Lipid Res · 2020
PMID 32062137
Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages
Atherosclerosis · 2020
PMID 32129440
Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes
Clin Sci (Lond) · 2020
PMID 32260160
Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells
Cells · 2020
PMID 32833187
Nobiletin Ameliorates NLRP3 Inflammasome-Mediated Inflammation Through Promoting Autophagy via the AMPK Pathway
Mol Neurobiol · 2020
PMID 32920004
Nobiletin ameliorates high-fat diet-induced vascular and renal changes by reducing inflammation with modulating AdipoR1 and TGF-β1 expression in rats
Life Sci · 2020