Holistic Remedies · Ingredient
Oleanolic acid
Formula: C30H48O3 · MW: 456.7110000000003 · Drug-likeness: 0.409
⚗️ Identity
Name
Oleanolic acid
Aliases / Synonyms
508-02-1; Oleanic acid; Caryophyllin; Astrantiagenin C; Giganteumgenin C; Virgaureagenin B; Oleanol; 3beta-Hydroxyolean-12-en-28-oic acid; oleonolic acid
🧪 Chemistry
Molecular Weight
456.7110
LogP
7.2336
Drug-likeness
0.409
Oral Bioavailability
29.0210
H-Bond Acceptors
2
H-Bond Donors
2
Rotatable Bonds
1
🔗 External References
1
Clinical Trials
1
Meta-Analyses
12
PubMed References
Top Conditions Studied with Oleanolic acid
📋 Sample Trials
NCT05529953
Bioavailability of Oleanolic Acid Formulated as Functional Olive Oil
Completed · Healthy Subjects|Bioavailability
📊 Sample Meta-Analyses
CRD42022344225
Mechanism of action of Oleanolic acid against insulin resistance and underlying oxidative stress on insulin-resistant animal models.
📚 Sample References
PMID 31825448
Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-κB and MAPK pathway
Food Funct · 2020
PMID 33062145
Oleanolic Acid Decreases IL-1 β-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF- κ B Axis in Osteoarthritis
Oxid Med Cell Longev · 2020
PMID 33130471
Oleanolic acid protects against mast cell-mediated allergic responses by suppressing Akt/NF-κB and STAT1 activation
Phytomedicine · 2021
PMID 34153323
Neuroprotective effects of oleanolic acid against cerebral ischemia-reperfusion injury in mice
Exp Neurol · 2021
PMID 34364837
Anticancer effects of oleanolic acid on human melanoma cells
Chem Biol Interact · 2021
PMID 34393781
Oleanolic Acid Improves Obesity-Related Inflammation and Insulin Resistance by Regulating Macrophages Activation
Front Pharmacol · 2021