Holistic Remedies · Ingredient
Piperine
Formula: C17H19NO3 · MW: 285.3430000000001 · Drug-likeness: 0.633
⚗️ Identity
Name
Piperine
Aliases / Synonyms
94-62-2; 1-Piperoylpiperidine; Piperin; Bioperine; 7780-20-3; Piperoylpiperidine; FEMA No. 2909; (E,E)-1-piperoylpiperidine; Piperidine, 1-piperoyl-, (E,E)-
🧪 Chemistry
Molecular Weight
285.3430
LogP
2.9972
Drug-likeness
0.633
Oral Bioavailability
42.5170
H-Bond Acceptors
3
Rotatable Bonds
3
🔗 External References
4
Clinical Trials
3
Meta-Analyses
24
PubMed References
Top Conditions Studied with Piperine
Deglutition Disorders 1
Bladder Spasm|Malignant Neoplasm|Pain|Urinary Urgency 1
We will study any disease connected to oxidative stress 1
Pharmacokinetic activity of conventional drugs co-administer 1
In this review, the effect of the curcumin and piperine comb 1
Prostate Cancer|Multiple Myeloma|Smoldering Multiple Myeloma 1
Focus of the Study: Normal Volunteers 1
📋 Sample Trials
NCT02598726
Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With Cancer
Active_Not_Recruiting · Phase 1 · Bladder Spasm|Malignant Neoplasm|Pain|Ur
NCT04731844
Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer
Recruiting · Phase 2 · Prostate Cancer|Multiple Myeloma|Smolder
NCT01324089
Resveratrol With or Without Piperine to Enhance Plasma Levels of Resveratrol
Completed · Focus of the Study: Normal Volunteers
NCT01383694
Effect Of Piperine In Patients With Oropharyngeal Dysphagia
Completed · Phase 1|Phase 2 · Deglutition Disorders
📊 Sample Meta-Analyses
CRD42020205056
Effects of Curcumin associated with piperine supplementation on oxidative stress biomarkers based on a randomized placebo-controlled trial
We will study any disease connected to oxidative stress
CRD42022320034
Cytochrome P450 mediated clinical pharmacokinetic alterations of Co-administered conventional drugs with Piperine- A :systematic review and meta-analysis.
Pharmacokinetic activity of conventional drugs co-administered with piperine.
CRD42023475116
The effect of the curcumin and piperine combination on glycemic control and liver function: A systematic review and Meta-Analysis of randomized controlled trial
In this review, the effect of the curcumin and piperine combination on glycemic
📚 Sample References
PMID 29378605
Piperine ameliorates SCA17 neuropathology by reducing ER stress
Mol Neurodegener · 2018
PMID 28330809
Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways
EBioMedicine · 2017
PMID 26297981
Inhibition of intestinal chloride secretion by piperine as a cellular basis for the anti-secretory effect of black peppers
Pharmacol Res · 2015
PMID 24326980
Effect of oral piperine on the swallow response of patients with oropharyngeal dysphagia
J Gastroenterol · 2014
PMID 31989711
The anti-anaphylactoid effects of Piperine through regulating MAS-related G protein-coupled receptor X2 activation
Phytother Res · 2020
PMID 32335165
Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination
Life Sci · 2020
🏥 Linked Health Topics 1 · matched via study conditions