natural remedies · Ingredient
Polydatin
Formula: C20H22O8 · MW: 390.3880000000001 · Drug-likeness: 0.405
⚗️ Identity
Name
Polydatin
Aliases / Synonyms
Piceid; 27208-80-6; 65914-17-2; Trans-Piceid; 3,4,5-Trihydroxystilbene-3-beta-monoglucoside; 3,4,5-Tsg; Resveratrol 3-beta-mono-D-glucoside; Resveratrol 3-O-beta-glucopyranoside; (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-(4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; resveratrol 3-O-beta-D-glucoside
🧪 Chemistry
Molecular Weight
390.3880
LogP
0.4469
Drug-likeness
0.405
Oral Bioavailability
21.4430
H-Bond Acceptors
8
H-Bond Donors
6
Rotatable Bonds
5
🔗 External References
0
Clinical Trials
1
Meta-Analyses
24
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
CRD42020196337
Polydatin in central nervous system disorders: a systematic review
📚 Sample References
PMID 30014902
Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
Redox Biol · 2018
PMID 29989844
Polydatin suppresses VEGF-induced angiogenesis through binding with VEGF and inhibiting its receptor signaling
FASEB J · 2019
PMID 28676456
Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury
Pharmacol Res · 2017
PMID 26833058
Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)
Cardiovasc Diabetol · 2016
PMID 23499836
Polydatin protects cardiac function against burn injury by inhibiting sarcoplasmic reticulum Ca2+ leak by reducing oxidative modification of ryanodine receptors
Free Radic Biol Med · 2013
PMID 22921781
Polydatin modulates Ca(2+) handling, excitation-contraction coupling and β-adrenergic signaling in rat ventricular myocytes
J Mol Cell Cardiol · 2012