natural remedies · Ingredient
Progesterone
Formula: C21H30O2 · MW: 314.4690000000001 · Drug-likeness: 0.701
⚗️ Identity
Name
Progesterone
Aliases / Synonyms
57-83-0; Pregn-4-ene-3,20-dione; Agolutin; Crinone; 4-Pregnene-3,20-dione; Prometrium; Utrogestan; Progestin; Luteol
🧪 Chemistry
Molecular Weight
314.4690
LogP
4.7235
Drug-likeness
0.701
Oral Bioavailability
13.6570
H-Bond Acceptors
2
Rotatable Bonds
1
🔗 External References
HERB DB
PubChem CID
CAS Number
DrugBank
InChIKey
RJKFOVLPORLFTN-LEKSSAKUSA-N
158
Clinical Trials
79
Meta-Analyses
10
PubMed References
Top Conditions Studied with Progesterone
📋 Sample Trials
NCT00000295
Progesterone Treatment in Female Smokers - 12
Completed · Phase 2 · Tobacco Use Disorder
NCT00029536
Progesterone vs Placebo Therapy for Women With Epilepsy
Completed · Phase 3 · Epilepsy
NCT00086177
Vaginal Progesterone to Reduce the Risk of Another Preterm Birth
Completed · Phase 3 · Pregnancy
NCT00218257
Progesterone for the Treatment of Cocaine Dependence - 1
Completed · Cocaine Abuse|Cocaine-Related Disorders
NCT00247169
Vaginal Progesterone in the Treatment of Cervical Dysplasia Grade I and II
Completed · Phase 2 · Cervical Intraepithelial Neoplasia
NCT00271206
Effect of Progesterone on Smoking Behavior in Male and Female Smokers
Completed · Phase 1 · Tobacco Use Disorder
📊 Sample Meta-Analyses
CRD42022358986
Progesterone luteal support and pregnancy outcomes in IVF: a systematic review and network meta-analysis
Luteal support in the prevention of unsuccessful IVF/ICSI, as reflected from cli
CRD42022342120
Response rates of MMR-deficient endometrial lesions to fertility-sparing progesterone treatment: a systematic review
The systematic review includes patients with endometrial cancers or pre-cancerou
CRD42016033946
Combinations of progesterone, cerclage and/or pessary for primary prevention of preterm birth: a systematic review and meta-analysis
Preterm birth is a major public health problem, and is the leading cause of infa
CRD42016043565
The comparative efficacy of cervical pessary, cerclage, vaginal and parenteral progesterone for the prevention of preterm birth in women with a short cervix and a singleton gestation: a systematic review and network meta-analysis
Preterm birth, short cervix, prevention of preterm birth
CRD42019117678
Progesterone treatment in patients undergoing cervical cerclage: a meta-analysis
Both progesterone and cervical cerclage are potentially effective treatments pre
CRD42019129296
Progesterone administration for the prevention of preterm birth and risk of developing diabetes mellitus: a meta-analysis
The preventive effect of progestogens was already discussed by Papiernik-Berkhau
📚 Sample References
PMID 32165211
Effects of progesterone on the cell number of gliomaspheres derived from human glioblastoma cell lines
Life Sci · 2020
PMID 32170571
Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxia-Ischemia
Cell Mol Neurobiol · 2020
PMID 32335121
Progesterone treatment following traumatic brain injury in the 11-day-old rat attenuates cognitive deficits and neuronal hyperexcitability in adolescence
Exp Neurol · 2020
PMID 32466385
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury
Int J Mol Sci · 2020
PMID 32689704
Benefits of progesterone on brain immaturity and white matter injury induced by chronic hypoxia in neonatal rats
J Thorac Cardiovasc Surg · 2020
PMID 33047378
Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair
Cell Prolif · 2020
🏥 Linked Health Topics 12 · matched via study conditions
Abortion, Habitual
syndrome
Epilepsy
syndrome
Infertility
phenotype
Female Infertility
phenotype
Polycystic Ovary Syndrome
syndrome
Premature Birth
phenotype
Cervical Intraepithelial Neoplasia
disease
Cocaine Dependence
disease
Female Puberty
phenotype
Progesterone Resistance
syndrome
Postmenopausal Endometrium
syndrome
Cannabis Use
disease