Holistic Remedies · Ingredient
Protocatechuic acid
Formula: C7H6O4 · MW: 154.121 · Drug-likeness: 0.522
⚗️ Identity
Name
Protocatechuic acid
Aliases / Synonyms
3,4-DIHYDROXYBENZOIC ACID; 99-50-3; Protocatehuic acid; 4-Carboxy-1,2-dihydroxybenzene; 4,5-Dihydroxybenzoic acid; Benzoic acid, 3,4-dihydroxy-; protocatechuate; MFCD00002509; CCRIS 6291
🧪 Chemistry
Molecular Weight
154.1210
LogP
0.7960
Drug-likeness
0.522
Oral Bioavailability
25.3660
H-Bond Acceptors
3
H-Bond Donors
3
Rotatable Bonds
1
🔗 External References
HERB DB
PubChem CID
CAS Number
DrugBank
InChIKey
YQUVCSBJEUQKSH-UHFFFAOYSA-N
0
Clinical Trials
0
Meta-Analyses
11
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 30326282
Protocatechuic acid-mediated DJ-1/PARK7 activation followed by PI3K/mTOR signaling pathway activation as a novel mechanism for protection against ketoprofen-induced oxidative damage in the gastrointestinal mucosa
Free Radic Biol Med · 2019
PMID 20840540
Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation
Br J Pharmacol · 2011
PMID 32510258
Protocatechuic acid inhibits proliferation, migration and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes
Artif Cells Nanomed Biotechnol · 2020
PMID 32520409
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease
Br J Pharmacol · 2020
PMID 33497687
Neuroprotective effects of protocatechuic acid on sodium arsenate induced toxicity in mice: Role of oxidative stress, inflammation, and apoptosis
Chem Biol Interact · 2021
PMID 33545736
Protocatechuic Acid Protects Platelets from Apoptosis via Inhibiting Oxidative Stress-Mediated PI3K/Akt/GSK3β Signaling
Thromb Haemost · 2021